Changes in synaptic efficacy and seizure susceptibility in rat brain slices following extremely low-frequency electromagnetic field exposure med./bio.

Aim of study (acc. to author)

Background/further details

Endpoint

• effects on the neurological system: alterations in basic synaptic functions, synaptic plasticity and seizure sensitivity

Exposure

• • 50/60 Hz
  • magnetic field

Extended view Compact view

Methods Endpoint/measurement parameters/methodology

• effects on the neurological system: alterations in basic synaptic functions (amplitude of evoked potentials and population spikes (stimulated by square voltage pulses), EPSP analysis; synaptic plasticity (short-term: paired-pulse facilitation; LTP: repetitive stimulation) and seizure sensitivity (e.g. latency of first seizure) (electrophysiological recordings with micro-electrodes)

Main outcome of study (acc. to author)

Study funded by

• Hungarian National Committee for Technological Development (OMFB), Hungary
• Hungarian Scientific Research Fund (OTKA), Hungary

Related articles

• Zheng Y et al. (2019): Effects of exposure to extremely low frequency electromagnetic fields on hippocampal long-term potentiation in hippocampal CA1 region
• Demir T et al. (2014): Investigation of the effects of magnetic field exposure on febrile seizure latency, seizure duration, and electroencephalographic recordings in a rat febrile convulsion model
• Komaki A et al. (2014): Effects of exposure to an extremely low frequency electromagnetic field on hippocampal long-term potentiation in rat
• Xiong J et al. (2013): Changes of dendritic spine density and morphology in the superficial layers of the medial entorhinal cortex induced by extremely low-frequency magnetic field exposure
• Balassa T et al. (2013): Changes in synaptic efficacy in rat brain slices following extremely low-frequency magnetic field exposure at embryonic and early postnatal age
• Fadakar K et al. (2013): Effects of extremely low frequency electromagnetic field (50 Hz) on pentylenetetrazol-induced seizures in mice
• Prochnow N et al. (2011): Electromagnetic field effect or simply stress? Effects of UMTS exposure on hippocampal longterm plasticity in the context of procedure related hormone release
• Moghadam MK et al. (2008): 50 Hz alternating extremely low frequency magnetic fields affect excitability, firing and action potential shape through interaction with ionic channels in snail neurones
• Deans JK et al. (2007): Sensitivity of coherent oscillations in rat hippocampus to AC electric fields
• Manikonda PK et al. (2007): Influence of extremely low frequency magnetic fields on Ca2+ signaling and NMDA receptor functions in rat hippocampus
• Marchionni I et al. (2006): Comparison between low-level 50 Hz and 900 MHz electromagnetic stimulation on single channel ionic currents and on firing frequency in dorsal root ganglion isolated neurons
• Jefferys JG et al. (2003): Effects of weak electric fields on the activity of neurons and neuronal networks
• Durand DM (2003): Electric field effects in hyperexcitable neural tissue: a review
• Saunders RD et al. (2002): Weak electric field interactions in the central nervous system
• Keskil IS et al. (2001): No effect of 50 Hz magnetic field observed in a pilot study on pentylenetetrazol-induced seizures and mortality in mice
• Valberg PA et al. (1997): Can low-level 50/60 Hz electric and magnetic fields cause biological effects?
• Bawin SM et al. (1996): Extremely-low-frequency magnetic fields disrupt rhythmic slow activity in rat hippocampal slices
• Bawin SM et al. (1989): Induction of delayed synchronized bursts in hippocampal slices by weak sine-wave stimulation; role of the NMDA receptor
• Bawin SM et al. (1986): Long-term effects of sinusoidal extracellular electric fields in penicillin-treated rat hippocampal slices
• Bawin SM et al. (1984): Influences of sinusoidal electric fields on excitability in the rat hippocampal slice