研究のタイプ: 医学／生物学の研究 (experimental study)

[超低周波磁界はラットの脳、腎臓および肝臓にマンガン蓄積を誘発する] med./bio.

Extremely low-frequency magnetic field induces manganese accumulation in brain, kidney and liver of rats

著者: Celik MS, Guven K, Akpolat V, Akdag MZ, Naziroglu M, Gul-Guven R, Celik MY, Erdogan S
掲載誌: Toxicol Ind Health 2015; 31 (6): 576-580
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この研究は、ラットを用いた実験で、超低周波磁界（ELF-MF）へのばく露がラットの腎臓、肝臓、脳におけるマンガン（Mn）蓄積に影響するか否かを調べた。40匹のラットをランダムに8群（n = 5）に分けた。4つの対照群は、体重1 kgあたり0、3.75、15、60 mgのMnをそれぞれ、2日に１回、45日間経口投与された。残りの4つのばく露も、それぞれの対照群と同様にMn投与を受け、さらに、ELF-MF（1.5 mT、50 Hz）のばく露を、1日4時間、週5日で、45日間受けた。最後のばく露の後、腎臓、肝臓、脳を摘出し、誘導結合プラズマ発光分析法により各組織のMn蓄積レベルを分析した。その結果、脳、腎臓、肝臓のMnレベルは、対照群に比べ、Mn投与群の方が高かった；また、脳、腎臓、肝臓のMnレベルは、Mn投与群に比べ、Mn投与+ ELF-MFばく露群の方が高かった、と報告している。

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研究目的（著者による）

To examine the effects of exposure to an extremely low frequency magnetic field on the accumulation of manganese in the kidney, liver and brain of rats.

詳細情報

To develop neurotoxicity prevention strategies, the effects of metals (for example manganese) on organisms exposed to extremely low frequency magnetic fields should be examined. Therefore, rats were divided into 8 groups (n=5 per group) and received different amounts of manganese every second day for 45 days: 1.) no manganese, 2.) 3.75 mg manganese per kg body weight, 3.) 15 mg manganese per kg body weight and 4.) 60 mg manganese per kg body weight. The rats were exposed or unexposed.

影響評価項目

ばく露

ばく露 パラメータ
ばく露1: 50 Hz
ばく露時間: 4 hours per day on 5 days/week during 45 days

ばく露1

主たる特性
周波数 50 Hz
タイプ
  • magnetic field
ばく露時間 4 hours per day on 5 days/week during 45 days
ばく露装置
ばく露の発生源／構造
チャンバの詳細 rats were housed individually in stainless steel methacrylate cages
ばく露装置の詳細 magnetic field was generated by two pairs of Helmholtz coils (70 cm in diameter) in a Faraday cage (130 x 65 x 80 cm); magnet was constructed by winding 125 turns of insulated soft copper wire with a diameter of 1.5 mm; coils were vertically placed facing one another; distance between coils: 47 cm
パラメータ
測定量 値 種別 Method Mass 備考
磁束密度 1.5 mT - 測定値 - -
Additional parameter details

geomagnetic field was 16 µT parallel to the exposure field and 37 µT perpendicular to the exposure field

ばく露を受けた生物:

方法 影響評価項目／測定パラメータ／方法

研究対象とした生物試料:

研究の主なアウトカム（著者による）

In exposed groups, the amount of manganese was significantly higher than in the unexposed groups. Only in the kidney, no significant differences were found between the exposed and the not exposed group which received no manganese.
The data indicate that exposure to an extremely low frequency magnetic field could lead to an accumulation of manganese in the kidney, liver and brain of rats.

研究の種別:

研究助成

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