• experimental
  
• epidemiological
  

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Medical/biological Study (experimental study)

The repair of gamma-ray-induced chromosomal damage in human lymphocytes after exposure to extremely low frequency electromagnetic fields. med./biol.

PubMed Entry

Aim of study (according to author)
To study the possibility that a electric or magnetic field in some way reduces the fidelity of repair of DNA damage (q.v. DNA repair) caused by a established mutagen.
Background/further details:
The in vitro assay of chromosomal aberrations induced in human lymphocytes by gamma irradiation was used.

Endpoint

• genotoxicity/mutation: fidelity of DNA repair

Exposure
General category: magnetic field, low frequency field, 50/60 Hz (AC)

Field characteristics	Parameters
field 1: 50 Hz exposure duration: continuous for 12 h	magnetic flux density: 230 µT
field 2: 50 Hz exposure duration: continuous for 12 h	magnetic flux density: 470 µT
field 3: 50 Hz exposure duration: continuous for 12 h	magnetic flux density: 700 µT

Exposed system:
intact cell/cell culture (in vitro)

Methods
Endpoint/Measurement parameters/Methodology

• genotoxicity/mutation: chromosomal damage (chromatid gaps, breaks and exchanges; presence of dicentric, centric ring and excess acentric chromosome aberrations; metaphase analysis; fluorescence plus Giemsa staining)

Main outcome of study (according to author)
No differences were revealed in the frequencies of gamma-induced chromosome aberrations observed in cells held in the electromagnetic fields compared with replicates held in a sham coil. Thus, the presence of these fields does not compromise directly or indirectly the repair of the gamma-ray induced lesions.

(Study character: medical/biological study, experimental study, full/main study)

Study funded by

• EMF Biological Research Trust (EMFBRT), UK

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