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Medical/biological Study (experimental study)

Evaluation of genotoxic effect of low level 50 Hz magnetic fields on human blood cells using different cytogenetic assays. med./biol.

By: Testa A, Cordelli E, Stronati L, Marino C, Lovisolo GA, Fresegna AM, Conti D, Villani P
Published in: Bioelectromagnetics 2004; 25 (8): 613 - 619 ( open external web page PubMed Entry , open external web page Journal web site )

Aim of study (according to author)
To study whether extremely low frequency magnetic fields may contribute to mutagenesis or carcinogenesis.
In a previous study (publication 10460) the authors have found that exposure of unstimulated human blood cells to 50 Hz, 1 mT for 2 h did not induce any DNA damage. The aim of this investigation is to study the potential genotoxic effect of a longer exposure time on PHA-stimulated human blood cells.
Background/further details:
In order to evaluate the possible genotoxic effects of extremely low frequency magnetic fields, human blood cells were exposed in vitro. Extremely low frequency pretreated cells were also irradiated with 1 Gy of X-ray to study the possible combined effect of extremely low frequency magnetic fields and ionizing radiation.

Endpoint

Exposure
General category: magnetic field, low frequency field, 50/60 Hz (AC)

Field characteristicsParameters
50 Hz
exposure duration: continuous for 48 h		magnetic flux density: 1 mT (75 V/m corresponding electric field)

FIELD View further expo parameters

Exposed system:
blood samples

Methods
Endpoint/Measurement parameters/Methodology

investigated material: DNA/RNA (in vitro), intact cell/cell culture (in vitro)

time of investigation: after exposure

Main outcome of study (according to author)
Data do not evidence any DNA damage induced by extremely low frequency magnetic fields exposure or any effect on cell proliferation. Results obtained from the combined exposure (extremely low frequency magnetic fields and ionizing radiation) do not suggest any synergistic or antagonistic effect.

(Study character: medical/biological study, experimental study, full/main study)

Study funded by

  • Ministero dell'Ambiente e della Tutela del Territorio e del Mar (Ministry of Environment and Territory), Italy

Related articles i
Glossary: 50 Hz, AC, alkaline, antagonistic, assay, biological, blood, blood cells, carcinogenesis, cell, cell culture, cell division, cell proliferation, cell viability, chromosome aberration, comet assay, cytogenetic, DNA, electric field, endpoint, evidence, exposed, exposure, extremely low frequency, frequency, full/main study, genotoxicity, Giemsa stain, Gy, human, induced, in vitro, ionizing radiation, irradiated, low frequency, magnetic fields, magnetic flux density, metaphase, micronuclei, mutagenesis, mutation, nuclear division index, PHA, potential, proliferation index, RNA, sister chromatid exchange, stimulated, synergistic, X-ray

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