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Medical/biological Study (experimental study)

Effects of pulsed electric fields on DNA of human lymphocytes. med./biol.

By: Delimaris J, Tsilimigaki S, Messini-Nicolaki N, Ziros E, Piperakis SM
Published in: Cell Biol Toxicol 2006; 22 (6): 409 - 415 ( open external web page PubMed Entry , open external web page Journal web site )

Aim of study (according to author)
To study the effects of pulsed low frequency electric fields (50 Hz) on DNA of human lymphocytes of 40 men.
Background/further details:
The influence of additional external factors (synergistic effects), such as hydrogen peroxide (0. 50, 100, or 150 µmol/l) and gamma radiation (0, 0.8, 2.5, or 4.2 Gy) was also determined.

Endpoint

Exposure
General category: signals/pulses, 50/60 Hz (AC)

Field characteristicsParameters
10 O - 50 Hz O
pulsed (PW)
exposure duration: continuous for 120 min		electric field strength: 400 kV/m

FIELD View further expo parameters

Exposed system:
intact cell/cell culture (in vitro)

Methods
Endpoint/Measurement parameters/Methodology

investigated material: DNA/RNA (in vitro), cell lysates

time of investigation: after exposure

Main outcome of study (according to author)
A significant increased DNA damage was found after exposure to the electric fields, compared to the controls. After 2 h incubation at 37°C, a proportion of damage was repaired.
Hydrogen peroxide and gamma radiation increased the DNA damage of lymphocytes exposed to pulsed electric fields according to the dose used, while the amount of the DNA repair was proportional to the damage.

(Study character: medical/biological study, experimental study, full/main study)

Study funded by

  • not stated

Related articles i
Glossary: 50 Hz, AC, biological, cell, cell culture, comet assay, DNA, DNA repair, dose, electric fields, electric field strength, endpoint, exposed, exposure, full/main study, gamma radiation, genotoxicity, Gy, human, hydrogen peroxide, incubation, in vitro, low frequency, lymphocytes, lysates, mutation, pulsed, pulses, PW, RNA, signals, significant, synergistic

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