• experimental
  
• epidemiological
  

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Medical/biological Study (experimental study)

Acute exposure to a 60 Hz magnetic field increases DNA strand breaks in rat brain cells. med./biol.

PubMed Entry

Journal web site

Aim of study (according to author)
To study the effects of acute exposure to a 60 Hz magnetic field on DNA damage in brain cells of the rat.
Background/further details:
DNA strand breaks have been correlated with carcinogenicity, cell death, aging, and neurodegenerative diseases.

Endpoint

• genotoxicity/mutation: DNA strand breaks

Exposure
General category: magnetic field, 50/60 Hz (AC)

Field characteristics	Parameters
60 Hz exposure duration: 2 h	power: 8 W max value magnetic flux density: 100 µT (0.25 mT and 0.5 mT)

Exposed system:
animal (species/strain): rat/Sprague-Dawley
whole body exposure

Methods
Endpoint/Measurement parameters/Methodology

• genotoxicity/mutation: DNA strand breaks (single-strand breaks, double-strand breaks; microgel electrophoresis assay (DNA migration))

Main outcome of study (according to author)
Acute (2 h) exposure of rats to a 60 Hz magnetic field caused a dose-dependent increase in DNA strand breaks in brain cells of the animals (4 h post-exposure). An increase in DNA single-strand breaks was found after exposure to magnetic fields of 0.1, 0.25, and 0.5 mT, whereas an increase in DNA double-strand breaks was revealed at 0.25 and 0.5 mT.

(Study character: medical/biological study, experimental study, full/main study, blind study)

Study funded by

• National Institute of Environmental Health Sciences (NIEHS), North Carolina, USA

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