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Medical/biological Study (experimental study)

The effect of extremely low frequency electromagnetic fields (ELF-EMF) on the frequency of micronuclei and sister chromatid exchange in human lymphocytes induced by benzo(a)pyrene. med./biol.

By: Cho YH, Chung HW
Published in: Toxicol Lett 2003; 143 (1): 37 - 44 ( open external web page PubMed Entry , open external web page Journal web site )

Aim of study (according to author)
To examine the interaction of extremely low frequency electromagnetic fields on the frequency of micronuclei and sister chromatid exchange induced by benzpyrene in human lymphocytes in vitro.
Background/further details:
The carcinogen benzpyrene was simultaneously applied to electromagnetic field exposure for 24 hours and after electromagnetic field exposure for 48 hours.
Following treatment groups were performed, each to electromagnetic field groups and sham exposed groups: 1. controls (no benzpyrene treatment), 2. controls plus dimethyl sulfoxide (DMSO), 3.-6. benzpyrene in four different concentrations (1, 5, 10 and 15 µg/ml).

Endpoint

Exposure
General category: magnetic field, 50/60 Hz (AC)

Field characteristicsParameters
60 Hz
exposure duration: continuous for 24 h		magnetic flux density: 0.8 mT

FIELD View further expo parameters

Exposed system:
intact cell/cell culture (in vitro)

Methods
Endpoint/Measurement parameters/Methodology

investigated material: intact cell/cell culture (in vitro), chromosomes

time of investigation: after exposure

Main outcome of study (according to author)
The frequencies of micronuclei and sister chromatid exchange induced by benzpyrene increased in a dose-dependent manner.
The co-exposure of cells to benzpyrene and extremely low frequency electromagnetic fields led to significant increases in the frequencies of micronuclei and sister chromatid exchange compared to benzpyrene treatment for 72 hours alone.
No significant difference was observed between electromagnetic field exposed and sham exposed control cells (group 1).
The results suggest that low magnetic flux density extremely low frequency electromagnetic fields could act as an enhancer of the initiation process of benzpyrene rather than as an initiator of mutagenic effects in human lymphocytes.

(Study character: medical/biological study, experimental study, full/main study)

Study funded by

  • not stated

Related articles i
Glossary: 50/60 Hz, AC, benzpyrene, biological, carcinogen, cell culture, cell division, cells, cell viability, chromosomes, co-exposure, DMSO, dose, electromagnetic field, endpoint, exposed, exposure, extremely low frequency, fluorescence plus Giemsa staining, frequencies, full/main study, genotoxicity, Giemsa staining, human, induced, initiation, in vitro, lymphocytes, magnetic field, magnetic flux density, micronuclei, mutagenic, mutation, proliferation, replication, sham exposed, significant, sister chromatid exchange

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