Epidemiologische Studie (Beobachtungsstudie)

Age of exposure to infections and risk of childhood leukaemia. epidem.

[Alter bei Exposition gegenüber Infektionen und das Risiko für Kinderleukämie].

Von: Petridou E, Kassimos D, Kalmanti M, Kosmidis H, Haidas S, Flytzani V, Tong D, Trichopoulos D

Veröffentlicht in: BMJ 1993; 307 (6907): 774

Ziel der Studie (lt. Autor)

Es wurde eine Fall-Kontroll-Studie in Griechenland durchgeführt, um mögliche Risikofaktoren für Kinderleukämie herauszufinden. Der Schwerpunkt in dieser Studie lag auf dem Risikofaktor Infektionen, es wurde jedoch auch die Exposition bei Magnetfeldern als möglicher Risikofaktor untersucht.

Expositionsgruppen

Gruppe	Charakteristik
Referenzgruppe 1	Abstand zu Hochspannungsfreileitungen: ≥ 50 m
Gruppe 2	Abstand zu Hochspannungsfreileitungen: 5 - 49 m
Gruppe 3	Abstand zu Hochspannungsfreileitungen: < 5 m
Referenzgruppe 4	Abstand zur Umspannstation: ≥ 100 m
Gruppe 5	Abstand zur Umspannstation: < 100 m

Population

Gruppe:
- Kinder
Alter: 0–14 Jahre
Beobachtungszeitraum: Juli 1987 - Juni 1991
Studienort: Griechenland (Athen und Umgebung, Kreta)

Fallgruppe

Merkmale: Kinderleukämie
Datenquelle: Kinderkrankenhäuser der Universitäten Athen und Kreta, Griechenland

Kontrollgruppe

Auswahl:
- krankenhausbezogen
Matching:
- Geschlecht
- Alter

Studiengröße

	Fälle	Kontrollen
Anzahl geeignet	183	-
Teilnehmerzahl	136	187

Statistische Analysemethode:

multiple lineare Regressionsanalyse

Schlussfolgerung (lt. Autor)

Die Ergebnisse zu den beiden Feldquellen von Magnetfeldern lassen entgegensetzte Schlussfolgerungen zu. Kinder, die in einem Abstand von weniger als 100 m von einer elektrischen Umspannstation entfernt lebten, hatten ein nicht-signifikant verringertes Risiko für Kinderleukämie (RR 0,35; KI 0,12-1,08). Dahingegen wiesen Kinder, die weniger als 5 m von Hochspannungsfreileitungen lebten, einen leichten, aber nicht signifikanten Anstieg des relativen Risikos für Kinderleukämie auf (RR 1,19; KI 0,59-2,41).

Studie gefördert durch

Ministry of Health, Greece
University of Harvard, USA

Themenverwandte Artikel

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