Studientyp:
Epidemiologische Studie
(Beobachtungsstudie)
Risk of hematological malignancies associated with magnetic fields exposure from power lines: a case-control study in two municipalities of northern Italy
epidem.
[Risiko von bösartigen hämatologischen Erkrankungen im Zusammenhang mit Magnetfeld-Expositionen durch Hochspannungsfreileitungen: eine Fall-Kontroll-Studie in zwei Stadtgebieten in Norditalien]
Von:
Malagoli C, Fabbi S, Teggi S, Calzari M, Poli M, Ballotti E, Notari B, Bruni M, Palazzi G, Paolucci P, Vinceti M
Veröffentlicht in: Environ Health 2010; 9: 16
Ziel der Studie (lt. Autor)
Weitere Details
Endpunkt/Art der Risikoabschätzung
Art der Abschätzung:
(relatives Risiko (RR))
Exposition
Abschätzung
Expositionsgruppen
|
Gruppe
|
Charakteristik
|
|
Referenzgruppe 1
|
Magnetfeld-Exposition: 0,1 - < 0,2 µT
|
|
Gruppe 2
|
Magnetfeld-Exposition: 0,2 - < 0,4 µT
|
|
Gruppe 3
|
Magnetfeld-Exposition: ≥ 0,4 µT
|
|
Referenzgruppe 4
|
Magnetfeld-Exposition: < 0,1 µT
|
|
Gruppe 5
|
Magnetfeld-Exposition: ≥ 0,1 µT
|
|
Gruppe 6
|
Magnetfeld-Exposition: ≥ 0,4 µT
|
Population
-
Gruppe:
-
Alter:
0–13 Jahre
-
Beobachtungszeitraum:
1986 - 2007
-
Studienort:
Italien (Stadtgebiete von Modena und Reggio Emilia)
Fallgruppe
Kontrollgruppe
-
Auswahl:
-
Matching:
- Geschlecht
- Alter
- Region
- Fall:Kontrolle = 1:4
Studiengröße
|
Fälle |
Kontrollen |
| Anzahl geeignet |
64 |
256 |
Statistische Analysemethode:
- unkonditionale logistische Regression
- konditionale logistische Regression
(
Anpassung:
- Bildungsstand des Vaters und der Mutter, Einkommen des Vaters
)
Ergebnisse (lt. Autor)
2 Fälle und 5 Kontrollen waren bei Magnetfeldern von Hochspannungsfreileitungen exponiert (1 Fall und 3 Kontrollen mit einer Magnetfeld-Stärke von 0,1 µT bis 0,2 µT; 1 Fall und 2 Kontrollen mit 0,4 µT und mehr).
Es wurde eine statistisch nicht-signifikant erhöhtes Risiko für Kinderleukämie bei Kindern beobachtet, die bei mehr als 0,1 µT (RR 6,7; KI 0,6-78,3) und bei mehr als 0,4 µT (RR 2,1; KI 0,2-26,2) exponiert waren. Bei Kindern mit einer Exposition über 0,1 µT wurde ein statistisch nicht-signifikant erhöhtes Risiko für akute lymphoblastische Leukämie gefunden (RR 5,3; KI 0,7-43,5). Die Autoren folgerten, dass die Ergebnisse anscheinend die Hypothese unterstützen, dass eine Exposition bei Magnetfeldern das Risiko für Kinderleukämie erhöht.
Einschränkungen (lt. Autor)
Die Ergebnisse basieren auf wenigen exponierten Fällen und Kontrollen.
Studie gefördert durch
-
Associazione Sostegno Ematologia Oncologia Pediatrica (ASEOP) ONLUS, Italy
-
Department of the Environment of Reggio Emilia Municipality, Italy
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