Radiofrequency radiation (900 MHz)-induced DNA damage and cell cycle arrest in testicular germ cells in swiss albino mice med./bio.

[Hochfrequenz-Befeldung (900 MHz)-induzierter DNA-Schaden und Zellzyklus-Arrest bei testikulären Keimzellen von Swiss Albino-Mäusen]

Ziel der Studie (lt. Autor)

Hintergrund/weitere Details

Endpunkt

• Wirkungen auf das Fortpflanzungssystem: Zellzyklus und DNA-Schäden in Spermien

Exposition/Befeldung (teilweise nur auf Englisch)

• • 900 MHz
  • hochfrequentes Feld
• • Mobilfunk
  • Mobiltelefon
  • GSM

Vollständige Ansicht Kompaktansicht

Methoden Endpunkt/Messparameter/Methodik

• Genotoxizität/Mutation: DNA-Schaden in Keimzellen (Strangbrüche, alkalischer Comet-Assay)
• Wirkungen auf das Fortpflanzungssystem: Spermien-Anzahl (insgesamt und fehlgebildete Spermien, Hämozytometer) und Kopf-Fehlbildungen (Kopf amorph, schnabelförmig, hakenförmig, hakenlos, nadelförmig, doppelköpfig, bananenförmig, zu groß oder zu klein; Eosin Y-Färbung, Lichtmikroskopie) im Nebenhoden, Gewebe-Index (Gewicht von Hoden, Nebenhoden und Samenleiter in Relation zum Körpergewicht), Hoden-Histologie (Menge an Samenkanälchen mit Gewebe-Verlust pro Maus, Epithel-Fläche pro Samenkanälchen; Hämatoxylin-Eosin-Färbung, Lichtmikroskopie), Keimzell-Reifung/Zellzyklus im Hoden (Gruppen 3-5, Anteile der Keimzell-Subpopulationen der Spermatiden, Spermatogonien und sekundären Spermatozyten sowie der primären Spermatozyten; Propidiumiodid-Färbung, Durchflusszytometrie), mitochondriales Membranpotenzial in Zellen des Hodens (Gruppen 3-5, JC-1-Färbung, kommerzielles Kit)

Hauptergebnis der Studie (lt. Autor)

Studie gefördert durch

• Department of Science and Technology (DST), India
• University Grants Commission (UGC), India

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