Studientyp:
Epidemiologische Studie
(Beobachtungsstudie)
Occupational exposure to extremely low frequency magnetic fields and risk of Alzheimer disease: A systematic review and meta-analysis
epidem.
[Berufliche Exposition bei niederfrequenten Magnetfelden und das Risiko für Alzheimer-Krankheit: ein systematischer Review und eine Meta-Analyse]
Von:
Jalilian H, Teshnizi SH, Röösli M, Neghab M
Veröffentlicht in: Neurotoxicology 2018; 69: 242-252
Ziel der Studie (lt. Autor)
Weitere Details
Folgende 20 Studien wurden eingeschlossen: Sobel et al (1995), Sobel et al (1996), Feychting et al (1998), Savitz et al (1998), Savitz et al (1998), Graves et al (1999), Noonan et al (2002), Feychting et al (2003), Hakansson et al (2003), Harmanci et al (2003), Qiu et al (2004), Park et al (2005), Davanipour et al (2007), Röösli et al (2007), Seidler et al (2007), Andel et al (2010), Sorahan and Mohammed (2014), Davanipour et al (2014), Koeman et al (2015) und Pedersen et al (2017).
Endpunkt/Art der Risikoabschätzung
Exposition
Abschätzung
Population
-
Gruppe:
-
Alter:
≥ 18 Jahre
-
Beobachtungszeitraum:
1950 - 2015
-
Studienort:
USA, Schweden, Finnland, Schweiz, Dänemark, Türkei, Deutschland, Großbritannien und die Niederlande
Statistische Analysemethode:
- Random-Effects-Modell, Metaregressions-Analyse, Heterogenitäts-Test, Funnel-Plot, Sensitivitätsanalyse
Ergebnisse (lt. Autor)
Es wurde ein erhöhtes Risiko für Alzheimer-Krankheit bei Beschäftigten mit einer beruflichen Exposition bei niederfrequenten Magnetfeldern beobachtet (RR 1,63; KI 1,35-1,96). Es wurden höhere Risikoschätzer bei Fall-Kontroll-Studien (OR 1,80; KI 1,40-2,32) als bei Kohortenstudien (RR 1,42; KI 1,08-1,87) gefunden.
Die Autoren schlussfolgern, dass eine berufliche Exposition bei niederfrequenten Magnetfeldern das Risiko für Alzheimer-Krankheit erhöhen könnte. Allerdings sollten die Ergebnisse wegen der mittleren bis hohen Heterogenität zwischen den Studien und Hinweisen auf Publikations-Bias mit Vorsicht interpretiert werden.
Studie gefördert durch
-
Shiraz University of Medical Sciences, Shiraz, Iran
Themenverwandte Artikel
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Huang LY et al.
(2020):
Association of Occupational Factors and Dementia or Cognitive Impairment: A Systematic Review and Meta-Analysis
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Touitou Y et al.
(2020):
Evaluation in humans of ELF-EMF exposure on chromogranin A, a marker of neuroendocrine tumors and stress
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Pedersen C et al.
(2017):
Occupational exposure to extremely low-frequency magnetic fields and risk for central nervous system disease: an update of a Danish cohort study among utility workers
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Koeman T et al.
(2015):
Occupational exposures and risk of dementia-related mortality in the prospective Netherlands Cohort Study
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Davanipour Z et al.
(2014):
Severe cognitive dysfunction and occupational extremely low frequency magnetic field exposure among elderly Mexican Americans
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Sorahan T et al.
(2014):
Neurodegenerative disease and magnetic field exposure in UK electricity supply workers
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Vergara X et al.
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Occupational exposure to extremely low-frequency magnetic fields and neurodegenerative disease: a meta-analysis
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Andel R et al.
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Work-related exposure to extremely low-frequency magnetic fields and dementia: results from the population-based study of dementia in Swedish twins
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Mortality from neurodegenerative disease and exposure to extremely low-frequency magnetic fields: 31 years of observations on Swiss railway employees
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