Studientyp:
Epidemiologische Studie
Amyotrophic Lateral Sclerosis and Occupational Exposures: A Systematic Literature Review and Meta-Analyses
epidem.
[Amyotrophe Lateralsklerose und berufliche Expositionen: systematischer Literatur-Review und Meta-Analyse]
Von:
Gunnarsson LG, Bodin L
Veröffentlicht in: Int J Environ Res Public Health 2018; 15 (11)
Ziel der Studie (lt. Autor)
Weitere Details
Folgende 17 Studien wurden in die Meta-Analyse eingeschlossen: Feychting et al. (2003), Fischer et al. (2015), Gunnarsson et al. (1991), Hakansson et al. (2003), Huss et al. (2015), Johansen et al. (1998),Johansen (2000), Noonan et al. (2002), Park et al. (2005), Parlett et al. (2011), Pedersen et al. (2017), Savitz et al. (1998a), Savitz et al. (1998b), Sorahan et al. (2007), Sorahan et al. (2014), Vergara et al. (2015) und Weißkopf et al. (2005).
Endpunkt/Art der Risikoabschätzung
Exposition
Abschätzung
Population
-
Gruppe:
-
Beobachtungszeitraum:
1991 - 2015
Statistische Analysemethode:
- Fixed-Effects-Modell, Random-Effects-Modell, Heterogenitäts-Test, Funnel-Plot
Ergebnisse (lt. Autor)
Insgesamt wurde ein leicht erhöhtes Risiko für amyotrophe Lateralsklerose bei Beschäftigten mit einer Exposition bei niederfrequenten Magnetfeldern (RR 1,23; KI 1,04-1,45) und bei Beschäftigten in elektrischen Berufen (RR 1,16; KI 1,00-1,35) beobachtet. Eine Analyse des Zeitraums 1991-2015, in der die Ergebnisse der früheren Studien schrittweise kumuliert wurden, zeigte eine fortschreitende Verminderung des Risikos auf. Für den Zeitraum 1991-2005 wurde ein höheres Risiko (RR 1,33; KI 1,33-1,58) im Vergleich zum Zeitraum 2006-2015 (RR 1,18; KI 1,07-1,31) gefunden.
Die Autoren schlussfolgern, dass die Ergebnisse auf einen möglichen Zusammenhang zwischen amyotropher Lateralsklerose und beruflicher Exposition bei niederfrequenten Magnetfeldern hindeuten.
Studie gefördert durch
-
nicht angegeben/keine Förderung
Themenverwandte Artikel
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Sorahan T et al.
(2022):
Motor neuron disease risk and magnetic field exposures
-
Jalilian H et al.
(2021):
Amyotrophic lateral sclerosis, occupational exposure to extremely low frequency magnetic fields and electric shocks: a systematic review and meta-analysis
-
Touitou Y et al.
(2020):
Evaluation in humans of ELF-EMF exposure on chromogranin A, a marker of neuroendocrine tumors and stress
-
Gunnarsson LG et al.
(2019):
Occupational Exposures and Neurodegenerative Diseases-A Systematic Literature Review and Meta-Analyses
-
Pedersen C et al.
(2017):
Occupational exposure to extremely low-frequency magnetic fields and risk for central nervous system disease: an update of a Danish cohort study among utility workers
-
Koeman T et al.
(2017):
Occupational exposure and amyotrophic lateral sclerosis in a prospective cohort
-
Fischer H et al.
(2015):
Occupational Exposure to Electric Shocks and Magnetic Fields and Amyotrophic Lateral Sclerosis in Sweden
-
Huss A et al.
(2015):
Occupational exposure to magnetic fields and electric shocks and risk of ALS: The Swiss National Cohort
-
Vergara X et al.
(2015):
Case-control study of occupational exposure to electric shocks and magnetic fields and mortality from amyotrophic lateral sclerosis in the US, 1991-1999
-
Capozzella A et al.
(2014):
Work related etiology of amyotrophic lateral sclerosis (ALS): a meta-analysis
-
Vergara X et al.
(2013):
Occupational exposure to extremely low-frequency magnetic fields and neurodegenerative disease: a meta-analysis
-
Zhou H et al.
(2012):
Association between Extremely Low-Frequency Electromagnetic Fields Occupations and Amyotrophic Lateral Sclerosis: A Meta-Analysis
-
Das K et al.
(2012):
Familial, environmental, and occupational risk factors in development of amyotrophic lateral sclerosis
-
Parlett LE et al.
(2011):
Evaluation of occupational exposure to magnetic fields and motor neuron disease mortality in a population-based cohort
-
Fang F et al.
(2009):
Workplace exposures and the risk of amyotrophic lateral sclerosis
-
Röösli M et al.
(2007):
Mortality from neurodegenerative disease and exposure to extremely low-frequency magnetic fields: 31 years of observations on Swiss railway employees
-
Sorahan T et al.
(2007):
Mortality from Alzheimer's, motor neurone and Parkinson's disease in relation to magnetic field exposure: findings from the study of UK electricity generation and transmission workers, 1973-2004
-
Weisskopf MG et al.
(2005):
Prospective study of occupation and amyotrophic lateral sclerosis mortality
-
Park RM et al.
(2005):
Potential occupational risks for neurodegenerative diseases
-
Hakansson N et al.
(2003):
Neurodegenerative diseases in welders and other workers exposed to high levels of magnetic fields
-
Feychting M et al.
(2003):
Occupational Magnetic Field Exposure and Neurodegenerative Disease
-
Noonan CW et al.
(2002):
Occupational exposure to magnetic fields in case-referent studies of neurodegenerative diseases
-
Savitz DA et al.
(1998):
Magnetic field exposure and neurodegenerative disease mortality among electric utility workers
-
Johansen C et al.
(1998):
Mortality from amyotrophic lateral sclerosis, other chronic disorders, and electric shocks among utility workers
-
Savitz DA et al.
(1998):
Electrical occupations and neurodegenerative disease: analysis of U.S. mortality data
-
Davanipour Z et al.
(1997):
Amyotrophic lateral sclerosis and occupational exposure to electromagnetic fields
-
Schulte PA et al.
(1996):
Neurodegenerative diseases: occupational occurrence and potential risk factors, 1982 through 1991
-
Strickland D et al.
(1996):
Amyotrophic lateral sclerosis and occupational history. A pilot case-control study
-
Gunnarsson LG et al.
(1992):
A case-control study of motor neurone disease: its relation to heritability, and occupational exposures, particularly to solvents
-
Gunnarsson LG et al.
(1991):
Amyotrophic lateral sclerosis in Sweden in relation to occupation
-
Deapen DM et al.
(1986):
A case-control study of amyotrophic lateral sclerosis
