To investigate the effect of a GSM radio frequency exposure on 6-sulphatoxymelatonin urinary excretion in rats.
Animals were exposed for 2 weeks (2 h daily) to 900 MHz (power density 100 µW/cm2) or 1800 MHz (power density 20 µW/cm2), modulated at 218 Hz. 6-sulphatoxymelatonin is the major metabolite of melatonin and could easily non-invasive determined in excreted urine.
A total of 72 animals were used in this study. Each experimental setup (i.e. 900 MHz or 1800 MHz) contained 36 animals, divided into 3 subgroups (12 animals each), and each setup was identical repeated three times consecutively. In each subgroup 6 animals were exposed or sham-exposed, respectively, and the obtained data were pooled. Thus, 18 animals were exposed or sham-exposed, respectively, in each experimental setup.
| Exposure | Parameters |
|---|---|
|
Exposure 1:
900 MHz
Modulation type:
pulsed
Exposure duration:
repeated daily exposure of 2 h/day for 14 days
|
|
|
Exposure 2:
1,800 MHz
Modulation type:
pulsed
Exposure duration:
repeated daily exposure of 2 h/day for 14 days
|
|
| Frequency | 900 MHz |
|---|---|
| Type | |
| Charakteristic |
|
| Exposure duration | repeated daily exposure of 2 h/day for 14 days |
| Exposure source |
|
|---|---|
| Chamber | The GTEM cell was positioned vertically, and the dominant E-field component was horizontal within the exposure area. |
| Setup | Six freely moving rats were kept in a purely plastic cage of 40 x 30 x 10 cm which was placed over the absorbent material of the GTEM cell at a distance of 0.85 m from the septum. The RF signal was produced by a mobile test phone and a power amplifier. |
| Additional info | The sham exposed control animals were handled just like the exposed ones, but without RF irradiation. |
| Measurand | Value | Type | Method | Mass | Remarks |
|---|---|---|---|---|---|
| electric field strength | 19.4 V/m | mean | measured | - | ± 2.8 V/m |
| power density | 100 µW/cm² | mean | measured | - | at 19.4 V/m |
| SAR | 0.012 W/g | - | calculated | whole body | 0.009-0.012 W/kg |
| Frequency | 1,800 MHz |
|---|---|
| Type | |
| Charakteristic |
|
| Exposure duration | repeated daily exposure of 2 h/day for 14 days |
| Measurand | Value | Type | Method | Mass | Remarks |
|---|---|---|---|---|---|
| electric field strength | 8.6 V/m | mean | measured | - | ± 1.2 V/m |
| power density | 20 µW/cm² | mean | measured | - | at 8.6 V/m |
| SAR | 0.045 W/kg | - | calculated | whole body | 0.022-0.045 W/kg |
Neither exposure to 900 MHz nor to 1800 MHz revealed statistically significant changes in the nocturnal excretion of 6-sulphatoxymelatonin in rats compared to sham-exposed control groups.
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