Rats were treated with the free scavengers melatonin and N-tert-butyl-alpha-phenylnitrone (PBN) to see whether they can block radiofrequency-induced DNA single-strand breaks and double-strand breaks (animals were treated before and after exposure).
rats were treated with melatonin or spin-trap compound N-tert-butyl-alpha-phenylnitrone (PBN) brfore or after exposure to EMF; experiments were done in four groups: i) EMF + drug ii) EMF only iii) sham exposure + drug iv) sham exposure
|Exposure duration||continuous for 2 h|
|Pulse width||2 µs|
|Packets per second||500|
Treatment of rats immediately before and after radiofrequency irradiation with either melatonin or the spin-trap compound N-tert-butyl-alpha-phenylnitrone (PBN) blocks the effects of radiofrequency irradiation (increase in DNA single-strand breaks and double-strand breaks). Since both melatonin and PBN are efficient free radical scavengers it is hypothesized that free radicals are involved in radiofrequency-induced DNA damage.
Since cumulated DNA strand breaks in brain cells can lead to neurodegenerative diseases and cancer and since an excess of free radicals has been suggested to be the cause of various human diseases, results from this study could have important implications for the health effects of radiofrequency exposure.