The healing effect of radiotherapy in cancer treatment relies on the radiosensitivity of target cancer cells. Finding a non invasive method to sensitize liver cancer cells to low doses of X-ray irradiation is of great importance.
Two groups were first exposed to 0, 2, 4, 6, 8, 10 Gy of X-ray and then two times to electromagnetic fields and sham exposure.
In a second experiment (only 2 Gy), it was tested whether more electromagnetic field exposures (6x vs. 2x) could contribute to higher apoptosis rates.
Two periods of electromagnetic field exposures following X-ray irradiation significantly increased the apoptosis rates of cells compared to those subjected to X-ray irradiation alone, with highest effects at doses of 4 and 6 Gy.
Six periods of electromagnetic field exposure significantly increased the apoptosis rate compared to fewer exposures (two times) when combined with 2 Gy X-ray irradiation.
Repetitive electromagnetic field exposure may increase the apoptotic effects when combined with low doses of X-ray.