Study type: Medical/biological study (experimental study)

Ouabain inhibition of kidney ATPase is altered by 9.14 GHz radiation med./bio.

By: Brown HD, Chattopadhyay SK
Published in: Bioelectromagnetics 1991; 12 (3): 137-143
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Aim of study (acc. to editor)

To investigate the activity of sodium potassium ATPase (Na+-K+-ATPase) from dog kidney regarding to CW microwave radiation and specific inhibition with ouabain at several temperatures (between 7° and 43.8°C)

Endpoint

Exposure

Exposure Parameters
Exposure 1: 9.14 GHz
Modulation type: CW
Exposure duration: 5 min
  • power: 200 mW (entered the reactor cell)
  • SAR: 20 mW/g unspecified
  • power: 2 µW (reflected energy)

Exposure 1

Main characteristics
Frequency 9.14 GHz
Type
Exposure duration 5 min
Modulation
Modulation type CW
Exposure setup
Exposure source
  • X-band generator, Lytton, magnetron-type
Additional info The reactor was housed in a metal box (reactor cell) / 5 x 4 x 3 inches.
Parameters
Measurand Value Type Method Mass Remarks
power 200 mW - cf. remarks - entered the reactor cell
SAR 20 mW/g unspecified estimated - -
power 2 µW - cf. remarks - reflected energy
Additional parameter details

185 W maximum power of the generator.

Exposed system:

Methods Endpoint/measurement parameters/methodology

Investigated system:
Time of investigation:
  • after exposure

Main outcome of study (acc. to author)

With ascending temperature an increase of unexposed sodium potassium ATPase (Na+-K+-ATPase) activity was observed. Ouabain inhibits specifically the Na+-K+-ATPase. In microwave exposed probes without ouabain treatment this increased activity was elevated. In ouabain treated and microwave exposed probes the activity was found to be less than in ouabain non-treated probes. The results suggest that microwave irradiation diminishes the effect of ouabain.

Study character:

Study funded by