Study type: Medical/biological study (experimental study)

Effects of extremely low frequency magnetic field on oxidative balance in brain of rats. med./bio.

Published in: J Physiol Pharmacol 2011; 62 (6): 657-661

Aim of study (acc. to author)

To study the effect of extremely low frequency magnetic fields most frequently used in magnetotherapy on reactive oxygen species generation in brain tissue of rats depending on the time of exposure.

Background/further details

30 animals were divided into one sham exposure group (n=10) and two exposure groups (each n=10; two different exposure durations: 30 min/day and 60 min/day).

Endpoint

Exposure

Exposure Parameters
Exposure 1: 40 Hz
Exposure duration: 30 min/day (group ii) respectively 60 min/day (group iii) for 10 days between 7 a.m. and 10 a.m.

General information

30 rats were divided into three groups of 10 animals each: i) control group ii) and iii) experimental groups with different exposure duration

Exposure 1

Main characteristics
Frequency 40 Hz
Type
Waveform
  • rectangular
Exposure duration 30 min/day (group ii) respectively 60 min/day (group iii) for 10 days between 7 a.m. and 10 a.m.
Exposure setup
Exposure source
  • apparatus used in magnetotherapy (MAGNETRONIK MF-10)
Setup rats in plastic containers were placed inside an applicator being part of the set for magnetotherapy
Sham exposure A sham exposure was conducted.
Parameters
Measurand Value Type Method Mass Remarks
magnetic flux density 7 mT - - - -

Exposed system:

Methods Endpoint/measurement parameters/methodology

Investigated system:
Investigated organ system:
Time of investigation:
  • after exposure

Main outcome of study (acc. to author)

Extremely low frequency magnetic fields of 7 mT, 40 Hz, 30 min/day for 10 days caused a significant increase in lipid peroxidation and insignificant increases in hydrogen peroxide and free sulfhydryl groups as well as an insignificant decrease in the total protein content (as compared with the control group).
The same extremely low frequency magnetic fields but applied for 60 min/day caused insignificant increases in lipid peroxidation and hydrogen peroxide as well as significant increases in free sulfhydryl groups and protein concentration in the brain homogenates (as compared with the control group).
The effect of extremely low frequency magnetic field irradiation on oxidative stress parameters depended on the duration of magnetic field exposure.

Study character:

Study funded by

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