Study type: Medical/biological study (experimental study)

Microwave attenuation of ethanol-induced hypothermia: ethanol tolerance, time course, exposure duration, and dose response studies. med./bio.

Published in: Bioelectromagnetics 1988; 9 (1): 63-78

Aim of study (acc. to author)

Four experiments were conducted to quantify the attenuation by microwave irradiation of ethanol-induced hypothermia: One experiment (tolerance) examined whether the microwave interaction with ethanol is related to processes that contribute to the development of tolerance to the hypothermic effect of ethanol. Two additional experiments (irradiation duration and effect duration) determined the duration of irradiation necessary to produce an attentuation of ethanol hypothermia at a particular dose of ethanol and the persistence of this effect. A final experiment (dose response) studies the interaction between microwave irradiation and various doses of ethanol.

Endpoint

Exposure

Exposure Parameters
Exposure 1: 2.45 GHz
Modulation type: CW
Exposure duration: 45 min for 8 days
Exposure 2: 2.45 GHz
Modulation type: CW
Exposure duration: 5 min
Exposure 3: 2.45 GHz
Modulation type: CW
Exposure duration: 15 min
Exposure 4: 2.45 GHz
Modulation type: CW
Exposure duration: 30 min
Exposure 5: 2.45 GHz
Modulation type: CW
Exposure duration: 60 min

Exposure 1

Main characteristics
Frequency 2.45 GHz
Type
Charakteristic
Polarization
  • circular
Exposure duration 45 min for 8 days
Modulation
Modulation type CW
Exposure setup
Exposure source
Setup Rats placed in Plexiglas hutches within the waveguide.
Parameters
Measurand Value Type Method Mass Remarks
SAR 3 mW/g mean calculated - -

Exposure 2

Main characteristics
Frequency 2.45 GHz
Type
Charakteristic
Polarization
  • circular
Exposure duration 5 min
Modulation
Modulation type CW
Exposure setup
Exposure source
Setup Rats placed in Plexiglas hutches within the waveguide.
Parameters
Measurand Value Type Method Mass Remarks
SAR 3 mW/g mean calculated - -

Exposure 3

Main characteristics
Frequency 2.45 GHz
Type
Charakteristic
Polarization
  • circular
Exposure duration 15 min
Modulation
Modulation type CW
Exposure setup
Exposure source
Setup Rats placed in Plexiglas hutches within the waveguide.
Parameters
Measurand Value Type Method Mass Remarks
SAR 3 mW/g mean calculated - -

Exposure 4

Main characteristics
Frequency 2.45 GHz
Type
Charakteristic
Polarization
  • circular
Exposure duration 30 min
Modulation
Modulation type CW
Exposure setup
Exposure source
Setup Rats placed in Plexiglas hutches within the waveguide.
Parameters
Measurand Value Type Method Mass Remarks
SAR 3 mW/g mean calculated - -

Exposure 5

Main characteristics
Frequency 2.45 GHz
Type
Charakteristic
Polarization
  • circular
Exposure duration 60 min
Modulation
Modulation type CW
Exposure setup
Exposure source
Setup Rats placed in Plexiglas hutches within the waveguide.
Parameters
Measurand Value Type Method Mass Remarks
SAR 3 mW/g mean calculated - -

Exposed system:

Methods Endpoint/measurement parameters/methodology

Investigated system:
Time of investigation:
  • before exposure
  • after exposure

Main outcome of study (acc. to author)

The results confirm that the hypothermic effect of ethanol can be attenuated by low-level microwave irradiation.
Tolerance experiment: It is demonstrated that while this effect persists beyond the initial exposure session, microwave irradiation contributes little to the rate of tolerance development. The data also suggest that there was no cumulative effect of daily microwave irradiation on the hypothermic response.
Irradiation duration experiment: It is demonstrated that the attenuation effect requires at least 45 min of irradiation, while the data of the duration of attenuation experiment demonstrate the acute nature of microwave attenuation of ethanol hypothermia.
Dose-response experiment: It is shown that the attenuation of ethanol hypothermia varies significantly with the dosage of ethanol injected. The difference in colonic temperature between exposed and sham-exposed groups was greater at lower doses than at higher doses.

Study character:

Study funded by

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