Angiogenesis discs (a sponge model) were implanted subcutaneously in mice. Vascular growth was stimulated by slow release of epidermal growth factor placed in the center of each disc. After 5 days of growth the discs were subjected to radiofrequency-induced hyperthermia (the thermal doses utilized were 41, 42, 43, and 44°C).
Exposure duration: 30 min
|Exposure duration||30 min|
No parameters are specified for this exposure.
An inverse relationship was revealed between vessel growth and exposure temperature. The extent of the fibroblastic growth was also inversely proportional to temperature.
Thus, in this system, the microvasculature shows dose-dependent damage by hyperthermia. This inhibition of angiogenesis may result from endothelial cell killing, interference with cell replication, inhibition of cell migration, or a combination of these mechanisms.