To study the effects of hyperthermia on rabbit hepatic vasculature histologically. The liver is a good model for investigating the vascular changes following hyperthermia because it contains 3 different types of vessels.
Exposure duration: 30 min
|Exposure duration||30 min|
Vascular damage following hyperthermia continued up to 24 h after heating for the three types of vasculature. Central veins were the most thermosensitive followed by portal veins, whereas hepatic arterioles were the most thermoresistant. The temperature causing 50% vascular damage 24 h after heating was 41.5-42.5°C, 42.5-43.5°C, and 44-45°C for central veins, portal veins, and arterioles, respectively. This differential thermal responsiveness of hepatic vasculature may be attributed to the histological structure of the vessels.