Study type: Medical/biological study (experimental study)

Assessing of plasma protein denaturation induced by exposure to cadmium, electromagnetic fields and their combined actions on rat. med./bio.

Published in: Electromagn Biol Med 2014; 33 (2): 147-153

Aim of study (acc. to author)

To investigate the effects of cadmium administration and/or extremely low frequency magnetic fields on potential oxidative damage in proteins in the blood of rats.

Background/further details

Cadmium is a heavy metal and carcinogenic to humans (class I carcinogen as classified by IARC).
Rats were divided into four groups (n=8, respectively): 1.) control group (saline administration), 2.) cadmium administration (3 mg CdCl2 per kg body weight), 3.) magnetic field exposure and 4.) cadmium administration + magnetic field exposure.

Endpoint

Exposure

Exposure Parameters
Exposure 1: 50 Hz
Exposure duration: for 30 consecutive days (remark EMF-Portal: not stated how many hours per day)

Exposure 1

Main characteristics
Frequency 50 Hz
Type
Exposure duration for 30 consecutive days (remark EMF-Portal: not stated how many hours per day)
Exposure setup
Exposure source
Setup an electromagnet with two coils was used; temperature was 23 ± 2°C
Parameters
Measurand Value Type Method Mass Remarks
magnetic flux density 0 T minimum measured - -
magnetic flux density 3.1 T maximum measured - -
magnetic flux density 10 mT - - - 10 mT/hour/day due to authors

Exposed system:

Methods Endpoint/measurement parameters/methodology

Investigated system:
Time of investigation:
  • after exposure

Main outcome of study (acc. to author)

Cadmium administration (group 2) or magnetic field exposure (group 3) caused a significant increase in the total oxidant status, the content of carbonyl groups and the electrical conductivity in comparison to the control group, while a combined treatment with cadmium and magnetic field (group 4) led to a further significant increase of these parameters compared to all other groups. Additionally, the SDS-PAGE profile was changed in all treatment groups (group 2, 3, and 4) when compared to the control group.
The authors conclude that combined treatment with cadmium and magnetic field exposure could increase the risk of plasma damage in rats via oxidative stress.

Study character:

Study funded by

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