Neuritin was recently discovered as an important growth factor for neural development, which promotes neuronal outgrowth and arborization in the brain. Mice with an overexpression of neuritin in the hippocampus were experimentally created (transfection with a viralvector) and used beside normal mice. Mice were divided into the following groups: exposure of normal mice to a magnetic field with 1) 0.4 mT or 2) 0.6 mT for 7 days and 3) with 1 mT for up to 21 days. Moreover, 4) neuritin-viral-transfected, 5) sham-viral-transfected and 6) saline-transfected mice were exposed to a magnetic field with 1 mT for 10 days. Additional sham exposedcontrol groups were used for each experiment. (remark EMF-Portal: not all group sizes were mentioned, but stated sizes were at least n=10).
the glass cage, containing 4 to 5 mice, was placed between the coils; the surfaces of the glass cage were parallel to the force lines of the magnetic field; temperature in glass cage under exposure conditions showed a difference of 0.4 ± 0.1°C compared to the sham exposure
Varani K et al.
(2012):
Effect of pulsed electromagnetic field exposure on adenosine receptors in rat brain.
Ongaro A et al.
(2012):
Electromagnetic fields (EMFs) and adenosine receptors modulate prostaglandin E(2) and cytokine release in human osteoarthritic synovial fibroblasts.
National Basic Research Program (Program 973), China
National Natural Science Foundation (NSFC), China
Shanghai Leading Academic Discipline Project, China
Related articles
Zhang Y et al.
(2017):
Theta-gamma coupling in hippocampus during working memory deficits induced by low frequency electromagnetic field exposure.
Lai J et al.
(2016):
Effects of extremely low frequency electromagnetic fields (100 µT) on behaviors in rats.
Zhang Y et al.
(2015):
Short-term effects of extremely low frequency electromagnetic fields exposure on Alzheimer's disease in rats.
Liu X et al.
(2015):
Improvement of spatial memory disorder and hippocampal damage by exposure to electromagnetic fields in an Alzheimer's disease rat model.
Podda MV et al.
(2014):
Extremely low-frequency electromagnetic fields enhance the survival of newborn neurons in the mouse hippocampus.
Xiong J et al.
(2013):
Changes of dendritic spine density and morphology in the superficial layers of the medial entorhinal cortex induced by extremely low-frequency magnetic field exposure.
Foroozandeh E et al.
(2013):
Toxic effects of 50 Hz electromagnetic field on memory consolidation in male and female mice.
Cuccurazzu B et al.
(2010):
Exposure to extremely low-frequency (50 Hz) electromagnetic fields enhances adult hippocampal neurogenesis in C57BL/6 mice.
Fu Y et al.
(2008):
Long-term exposure to extremely low-frequency magnetic fields impairs spatial recognition memory in mice.
Liu T et al.
(2008):
Chronic exposure to low-intensity magnetic field improves acquisition and maintenance of memory.
Sienkiewicz ZJ et al.
(2001):
Single, brief exposure to a 50 Hz magnetic field does not affect the performance of an object recognition task in adult mice.
