Study type: Medical/biological study (experimental study)

Exposure of female rats to a 100-microT 50 Hz magnetic field does not induce consistent changes in nocturnal levels of melatonin. med./bio.

Published in: Radiat Res 1998; 150 (5): 557-567

Aim of study (acc. to author)

To investigate the effect of a 50 Hz/100 µT magnetic field exposure on melatonin levels in DMBA-treated rats.

Background/further details

Several experimental attempts were accomplished: A) Long term magnetic field exposure (13 weeks) with or without DMBA treatment and determination of nocturnal melatonin levels in pineal gland and blood serum 5 hours after the onset of dark phase. B) Effects of a two week magnetic field exposure on plasma melatonin levels determined 3, 5, and 6 hours after the onset of dark phase. C) Effects of different magnetic field exposure times (i.e. 4, 8, and 13 weeks) on plasma melatonin determination at different time points (5 and 6 hours after the onset of dark phase. D) Effects of short term magnetic field exposure (i.e. 1 day, 1 week, 2 weeks) on plasma melatonin levels. Several experimental attemptes were accomplished: A) Long term magnetic field exposure (13 weeks) with or without DMBA treatment and determination of nocturnal melatonin levels in pineal gland and blood serum 5 hours after the onset of dark phase. B) Effects of a two week magnetic field exposure on plasma melatonin levels determined 3, 5, and 6 hours after the onset of dark phase. C) Effects of different magnetic field exposure times (i.e. 4, 8, and 13 weeks) on plasma melatonin determination at different time points (5 and 6 hours after the onset of dark phase. D) Effects of short term magnetic field exposure (i.e. 1 day, 1 week, 2 weeks) on plasma melatonin levels.

Endpoint

Exposure

Exposure Parameters
Exposure 1: 50 Hz
Exposure duration: 24 h/day, 7 days/week, over 13 weeks

Exposure 1

Main characteristics
Frequency 50 Hz
Type
Waveform
Exposure duration 24 h/day, 7 days/week, over 13 weeks
Additional info horizontal polarization
Exposure setup
Exposure source
Parameters
Measurand Value Type Method Mass Remarks
magnetic flux density 100 µT effective value - - -

Exposed system:

Methods Endpoint/measurement parameters/methodology

Investigated material:
Investigated organ system:
Time of investigation:
  • after exposure

Main outcome of study (acc. to author)

No consistent of the magnetic field exposure up to 13 weeks on nocturnal melatonin levels in the pineal gland or blood serum could be demonstrated by this study.

Study character:

Study funded by

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