Study type: Therapeutical study (experimental study, observational study)

Hyperthermia and radiotherapy for inoperable squamous cell carcinoma metastatic to cervical lymph nodes from an unknown primary site med. app.

By: Amichetti M, Romano M, Cristoforetti L, Valdagni R
Published in: Int J Hyperthermia 2000; 16 (1): 85-93
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Aim of study (acc. to author)

To present results obtained using a treatment combination of radiotherapy and local hyperthermia in patients with an unknwon primary carcinoma metastatic to cervical lymph nodes.

Endpoint

Exposure

Exposure Parameters
Exposure 1: 280–300 MHz -

Exposure 1

Main characteristics
Frequency 280–300 MHz
Type
Additional info No details available.
Exposure setup
Exposure source
  • BSD 1000 unit using an applicator model MA150 with aperture size 10 cm x 13 cm
Parameters

No parameters are specified for this exposure.

Exposed system:

Methods Endpoint/measurement parameters/methodology

Investigated system:
Investigated organ system:
Time of investigation:
  • during exposure
  • after exposure

Main outcome of study (acc. to author)

Nine patients achieved a complete, and four a partial response for an overall response rate of 86.5%. Acute and late toxicity was mild. The actuarial overall survival is 29%. Five patients developed distant metastases and died of disease, two experienced nodal recurrence and two patients died of other unrelated causes.
The addition of local microwave hyperthermia to radiotherapy in the treatment of metastatic squamous cell carcinoma of the neck leads to good local control with moderate toxicity.

Study character:

Study funded by