Study type: Medical/biological study (experimental study)

Studies on the interaction of microwave radiation with cholinesterase med./bio.

By: Olcerst RB, Rabinowitz JR
Published in: Radiat Environ Biophys 1978; 15 (3): 289-295
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Aim of study (acc. to author)

To investigate the effect of microwave exposure on the activity of acetylcholinesterase in vitro.

Background/further details

Commercial avilable pure enzyme as well as defibrinated rabbit blood samples were tested.

Endpoint

Exposure

Exposure Parameters
Exposure 1: 2.45 GHz
Modulation type: CW
Exposure duration: continuous for 30 min
uncooled
Exposure 2: 2.45 GHz
Modulation type: CW
Exposure duration: continuous for 3 hr
cooled
Exposure 3: 2.45 GHz
Modulation type: pulsed
Exposure duration: continuous for 3 hr
cooled
Exposure 4: 2.45 GHz
Modulation type: CW
Exposure duration: continuous for 3 hr
cooled

Exposure 1

Main characteristics
Frequency 2.45 GHz
Type
Exposure duration continuous for 30 min
Additional info uncooled
Modulation
Modulation type CW
Exposure setup
Exposure source
Distance between exposed object and exposure source 0.127 m
Chamber temperature jacketed quartz spectrometer cell
Parameters
Measurand Value Type Method Mass Remarks
power density 10 mW/cm² minimum measured - -
power density 125 mW/cm² maximum measured - -

Exposure 2

Main characteristics
Frequency 2.45 GHz
Type
Exposure duration continuous for 3 hr
Additional info cooled
Modulation
Modulation type CW
Exposure setup
Exposure source
Distance between exposed object and exposure source 0.127 m
Chamber temperature jacketed quartz spectrometer cell; cooled
Parameters
Measurand Value Type Method Mass Remarks
power density 25 mW/cm² - measured - -

Exposure 3

Main characteristics
Frequency 2.45 GHz
Type
Exposure duration continuous for 3 hr
Additional info cooled
Modulation
Modulation type pulsed
Pulse width 750 µs
Additional info

repetition rate: 0.71 pulses/ms
Exposure setup
Exposure source
Distance between exposed object and exposure source 0.127 m
Chamber temperature jacketed quartz spectrometer cell; cooled
Parameters
Measurand Value Type Method Mass Remarks
power density 21 mW/cm² - measured - -
power density 35 mW/cm² - measured - -
power density 64 mW/cm² - measured - -

Exposure 4

Main characteristics
Frequency 2.45 GHz
Type
Exposure duration continuous for 3 hr
Additional info cooled
Modulation
Modulation type CW
Exposure setup
Exposure source
Distance between exposed object and exposure source 0.127 m
Chamber temperature jacketed quartz spectrometer cell; cooled
Parameters
Measurand Value Type Method Mass Remarks
power density 21 mW/cm² - measured - -
power density 35 mW/cm² - measured - -
power density 64 mW/cm² - measured - -

Exposed system:

Methods Endpoint/measurement parameters/methodology

Investigated system:
Time of investigation:
  • after exposure

Main outcome of study (acc. to author)

No direct effect of microwave exposure on the activity of acetylcholinesterase was found, neither for commercial available purified enzyme in aqueous solution nor in defibrinated rabbit blood samples. High absorbed power leads to an thermal denaturation of the enzyme in uncooled experiments and therefore causes a lack of activity.

Study character:

Study funded by