Study type: Medical/biological study (experimental study)

Microwave hyperthermia-induced blood-brain barrier alterations. med./bio.

Published in: Radiat Res 1982; 89 (1): 77-87

Aim of study (acc. to author)

Examination of mechanisms of interaction between microwave radiation and the blood-brain barrier and correlation of any change in permeability with the quantity and distribution of absorbed microwave energy.

Endpoint

Exposure

Exposure Parameters
Exposure 1: 2.45 GHz
Modulation type: pulsed
Exposure duration: continuous; 5-20 min
Exposure 2: 2.45 GHz
Modulation type: pulsed
Exposure duration: continuous; 20 min
Exposure 3: 2.45 GHz
Modulation type: pulsed
Exposure duration: continuous; 10 min

Exposure 1

Main characteristics
Frequency 2.45 GHz
Type
Exposure duration continuous; 5-20 min
Modulation
Modulation type pulsed
Pulse width 10 µs
Repetition frequency 500 Hz
Additional info

rectangular pulses

Exposure setup
Exposure source
  • dielectrically loaded coaxial applicator Elmed, Addison, IL, aperture diameter 14 mm
Setup Animal was placed prone over a polyfoam body holder with the top of the head held horizontal, the microwave applicator in direct contact with the left side of the rat`s head.
Parameters
Measurand Value Type Method Mass Remarks
power density 3 W/cm² mean calculated - -

Exposure 2

Main characteristics
Frequency 2.45 GHz
Type
Waveform
Exposure duration continuous; 20 min
Modulation
Modulation type pulsed
Pulse width 10 µs
Packets per second 500
Additional info

rectangular pulses

Exposure setup
Exposure source
Parameters
Measurand Value Type Method Mass Remarks
power density 1 W/cm² mean calculated - to 3.5 W/cm²

Exposure 3

Main characteristics
Frequency 2.45 GHz
Type
Waveform
Exposure duration continuous; 10 min
Modulation
Modulation type pulsed
Pulse width 10 µs
Packets per second 500
Additional info

rectangular pulses

Exposure setup
Exposure source
Parameters
Measurand Value Type Method Mass Remarks
power density 3 W/cm² mean calculated - -

Reference articles

Exposed system:

Methods Endpoint/measurement parameters/methodology

Investigated system:
Investigated organ system:
Time of investigation:
  • during exposure
  • after exposure

Main outcome of study (acc. to author)

Irradiation with pulsed 2450 MHz microwaves induced increased permeability of blood-brain barrier only at power densities causing hyperthermia of the brain.

Study character:

Study funded by