Study type: Technical/dosimetric study (experimental study)

Effect of microwave irradiation on brain tissue structure and catecholamine distribution. tech./dosim.

Published in: Psychopharmacology (Berl) 1980; 67 (2): 119-123

Aim of study (acc. to author)

During the course of studies on the usefulness of microwave irradiation for rapid inactivation of enzymes for assaying regional catecholamines in animal brains, questions have been raised regarding the possibility of tissue damage resulting from irradiation, as well as transformation and cell disruption followed by the flowing out of neurotransmitters. To find a response to these questions, light and electron microscopic examinations were carried out on corpus striatum and locus coeruleus sections and compared with sections obtained in a previous decapitation study.

Endpoint

Exposure

Exposure Parameters
Exposure 1: 2.45 GHz
Exposure duration: 5 s
Exposure 2: 2.45 GHz
Exposure duration: 1,5 s

General information

Maruyama and Kussaka, 1978; Maruyama et al. 1978b;

Exposure 1

Main characteristics
Frequency 2.45 GHz
Exposure duration 5 s
Exposure setup
Parameters
Measurand Value Type Method Mass Remarks
power 1.3 kW - - - -

Exposure 2

Main characteristics
Frequency 2.45 GHz
Exposure duration 1,5 s
Exposure setup
Parameters
Measurand Value Type Method Mass Remarks
power 5 kW - - - -

Exposed system:

Methods Endpoint/measurement parameters/methodology

Investigated system:
Investigated organ system:
Time of investigation:
  • after exposure

Main outcome of study (acc. to author)

The interface of the striatum and the cortex showed no trace of tissue breakdown. Transformed cells, vacuolation, and indications of pycnotic degeneration in the nucleus were observed in locus coeruleus after exposure, but the shapes of these cells were well defined. Electron microscopic photographs of synapses in the same area showed membrane damage after irradiation for 5 s at 1.3 kW, but synaptic vesicles were clearly defined. The authors concluded that the increased catecholamine levels (as reported in previous studies) were not the result of tissue disruption following rapid heating of the brain by irradiation.

Study character:

Study funded by