Study type: Medical/biological study (experimental study)

Regional distribution of Hsp70 in the CNS of young and old food-restricted rats following hyperthermia. med./bio.

Published in: Brain Res Bull 2001; 55 (3): 367-374

Aim of study (acc. to author)

To examine HSP70 (heat shock protein 70) expression in the brains of young (6 months) and old (25 months) rats exposed to high-power microwaves.

Background/further details

A method of rapid heating was used that has been shown to be a potent stimulus for Hsp70 expression in the CNS. Furthermore, a number of selected brain regions was examined in order to perform a more complete survey of the Hsp70 response.

Endpoint

Exposure

Exposure Parameters
Exposure 1: 2.06 GHz
Exposure duration: 30 s

Exposure 1

Main characteristics
Frequency 2.06 GHz
Type
Charakteristic
Exposure duration 30 s
Additional info khe-polarization.
Exposure setup
Exposure source
Chamber Anechoic chamber (21.5-24°C, 50-60% humidity)
Setup rats placed in styrofoam restrainer with polyvinyl chloride head gate and plexiglass tail gate; the head gate was placed between the head and the neck so that the head of the rat extended outside the restrainer
Additional info head pointing towards antenna
Parameters
Measurand Value Type Method Mass Remarks
power density 2.2 W/cm² mean measured - -
SAR 1.231 mW/g average over time - - -

Exposed system:

Methods Endpoint/measurement parameters/methodology

Investigated system:
Investigated organ system:
Time of investigation:
  • after exposure

Main outcome of study (acc. to author)

The results demonstrate that age does not dramatically influence the ability to the CNS to produce Hsp70 in response to hyperthermia. In some areas of the brain, age resulted in an attenuation of the heat shock response to hyperthermia, while in other areas of the brain no such age-related attenuation was present.

Study character:

Study funded by