A method of rapid heating was used that has been shown to be a potent stimulus for Hsp70expression in the CNS. Furthermore, a number of selected brain regions was examined in order to perform a more complete survey of the Hsp70 response.
rats placed in styrofoam restrainer with polyvinyl chloride head gate and plexiglass tail gate; the head gate was placed between the head and the neck so that the head of the rat extended outside the restrainer
The results demonstrate that age does not dramatically influence the ability to the CNS to produce Hsp70 in response to hyperthermia. In some areas of the brain, age resulted in an attenuation of the heat shock response to hyperthermia, while in other areas of the brain no such age-related attenuation was present.