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NIRS has been well established as a tool to study activity of the brain and e.g. applied to record changes in oxy-hemoglobin and deoxy-hemoglobin concentrations in the visual and motor cortices during functional stimulation. Oxy-hemoglobin and deoxy-hemoglobin are related to cerebral blood flow and cerebral blood volume.
Compared to previous studies using positron emission tomography, NIRS provides a much higher time resolution, which allows investigating the short term effects efficiently, non-invasively, without the use of radioactive tracers and with high sensitivity.
|ばく露時間||15 cycles: 20 s exposure (intermittend 2 s on/2 s off) and 60 s rest (total of 24 min.)|
|Repetition frequency||217 Hz|
|ばく露装置の詳細||The antenna was positioned on a location close to the left ear.|
During exposure (within 20 s) borderline significant short term responses of oxy-hemoglobin and deoxy-hemoglobin concentrations were observed, which correspond to a decrease of cerebral blood flow and cerebral blood volume and were much smaller than regular physiological changes elicited e.g. by functional activation of the brain.
There was no detectable dose-response relation or long term response within 20 minutes.