研究のタイプ: 医学/生物学の研究 (experimental study)

[携帯電話放射はヒト内皮細胞株における遺伝子およびタンパク質発現の変化を引き起こし、その反応はゲノムおよびプロテオーム依存的と見られる] med./bio.

Mobile phone radiation causes changes in gene and protein expression in human endothelial cell lines and the response seems to be genome- and proteome-dependent.

掲載誌: Proteomics 2006; 6 (17): 4769-4780

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研究目的(著者による)

To study the effects of 900 MHz GSM mobile phone irradiation on the gene and protein expression in two closely related human endothelial cell lines.

詳細情報

Gene expression changes were examined in three experiments and investigation of protein expression changes were replicated in ten experiments.
The work is part of the REFLEX project (Risk Evaluation of Potential Environmental Hazards From Low Energy Electromagnetic Field Exposure Using Sensitive in vitro Methods), funded by the European Union.

影響評価項目

ばく露

ばく露 パラメータ
ばく露1: 900 MHz
Modulation type: pulsed
ばく露時間: continuous for 1 h
  • SAR: 2.8 W/kg mean

ばく露1

主たる特性
周波数 900 MHz
タイプ
  • electromagnetic field
ばく露時間 continuous for 1 h
Modulation
Modulation type pulsed
Additional information

GSM signal

ばく露装置
ばく露装置の詳細 Cells were irradiated with a simulated mobile phone microwave radiation as described in [Leszczynski et al., 2002].
Sham exposure A sham exposure was conducted.
Additional information The temperature of the cells and the culture medium remained at 37 ± 0.2°C throughout the exposure period.
パラメータ
測定量 種別 Method Mass 備考
SAR 2.8 W/kg mean 測定値および計算値 - -

Reference articles

  • Leszczynski D et al. (2002): [ヒトの上皮細胞の携帯電話によるhsp27/p38MAPKストレスの非熱活性化:がん関連とBBB関連効果の分子的メカニズム]

ばく露を受けた生物:

方法 影響評価項目/測定パラメータ/方法

研究対象とした生物試料:
調査の時期:
  • ばく露後

研究の主なアウトカム(著者による)

The data showed that gene and protein expression are altered in both cell lines in response to mobile phone irradiation. Furthermore, different genes and different proteins were affected by the same exposure in both cell lines. This suggest that under these experimental conditions the cell responses might be genome- and proteome-dependent.

研究の種別:

研究助成

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