研究のタイプ: 医学/生物学の研究 (experimental study)

[in vivoラット脳の血液脳脊髄液関門に対する無線周波電磁界ばく露の生物学的な影響] med./bio.

Biological effect on blood cerebrospinal fluid barrier due to radio frequency electromagnetic fields exposure of the rat brain in vivo.

掲載誌: Environmentalist 2007; 27 (4): 489-492

この研究は、高周波電磁界(RFEMF)ばく露による血液脳脊髄液関門(BCB)機能への影響を調べた。この目的のため、微小灌流法を用いてBCB機能をリアルタイムで測定する実験系を作成し、ラットの短時間ばく露実験を行った。RF-EMFへの30分間の単回ばく露を、成獣ラットでは脳平均SARが9.5 W / kg、若齢ラットではそれが10.4 W / kgとなるばく露レベルで行った結果、ラットのBCB機能への影響は見られなかった、と報告している。

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研究目的(著者による)

This study was conducted to examine the radio frequency effect on the blood-cerebrospinal fluid barrier permeability in rats.

詳細情報

The blood-cerebrospinal fluid barrier is a physiological barrier between blood circulation and cerebrospinal fluid system in brain with a complete permeability only for water and water soluable gases.
A cannula was implanted into lateral brain ventricle of both juvenile and adult male rats to gain cerebrospinal fluid. After FITC-albumin injection into caudal vein fluorescence intensity of FITC-albumin was measured in cerebrospinal fluid for 180 minutes.

影響評価項目

ばく露

ばく露 パラメータ
ばく露1: 1.5 GHz
Modulation type: pulsed
ばく露時間: continuous for 30 min
adult rats
  • SAR: 0.5 W/kg average over mass (brain)
  • SAR: 2 W/kg average over mass (brain)
  • SAR: 9.5 W/kg average over mass (brain)
ばく露2: 1.5 GHz
Modulation type: pulsed
ばく露時間: continuous for 30 min
juvenile rats
  • SAR: 0.6 W/kg average over mass (brain)
  • SAR: 2.2 W/kg average over mass (brain)
  • SAR: 10.4 W/kg average over mass (brain)

ばく露1

主たる特性
周波数 1.5 GHz
タイプ
  • electromagnetic field
特性
  • near field
ばく露時間 continuous for 30 min
Additional information adult rats
Modulation
Modulation type pulsed
Additional information

TDMA signal for Japanese PDC systems

ばく露装置
ばく露の発生源/構造
  • 8-shaped loop antenna
ばく露装置の詳細 The rat's head was locally exposed by the antenna placed 5 mm upward to the parietal region.
Sham exposure A sham exposure was conducted.
パラメータ
測定量 種別 Method Mass 備考
SAR 0.5 W/kg average over mass - brain -
SAR 2 W/kg average over mass - brain -
SAR 9.5 W/kg average over mass - brain -

ばく露2

主たる特性
周波数 1.5 GHz
タイプ
  • electromagnetic field
特性
  • near field
ばく露時間 continuous for 30 min
Additional information juvenile rats
Modulation
Modulation type pulsed
Additional information

TDMA signal for Japanese PDC systems

ばく露装置
ばく露の発生源/構造
  • E1と同じ装置
Sham exposure A sham exposure was conducted.
パラメータ
測定量 種別 Method Mass 備考
SAR 0.6 W/kg average over mass - brain -
SAR 2.2 W/kg average over mass - brain -
SAR 10.4 W/kg average over mass - brain -

ばく露を受けた生物:

方法 影響評価項目/測定パラメータ/方法

研究対象とした生物試料:
研究対象とした臓器系:
調査の時期:
  • ばく露後

研究の主なアウトカム(著者による)

No statistically significant effects of radio frequency exposure on blood-cerebrospinal fluid barrier permeability in rats were observed.

研究の種別:

研究助成

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