この研究は、コード分割多重アクセス（CDMA）携帯電話からの無線周波（RF）信号へのばく露がDNA完全性に与える影響を評価した。6人の健康な男性の全血サンプルにCDMA携帯電話RF信号ばく露（835 MHz、SAR=1.17 W/ kg、ばく露時間は連続して1時間または2時間）を与えた。DNA損傷の評価にはアルカリコメットアッセイを用いた。RF単独ばく露の他にRF信号とアフィジコリン（APC：DNA修復阻害剤：濃度は0.2または2 μg/ ml）の組み合わせばく露も行った。ばく露の2時間後にDNA修復効率も調べた。その結果、RF信号とAPC（0.2μg/ ml）は、それぞれ単独または組み合わせのばく露において、擬似ばく露と比較して、有意なDNA損傷は見られなかった；RF信号と組み合わせるAPCの濃度によってDNA損傷は有意に異なった；2 mg / ml濃度のAPC単独ばく露でも、擬似のばく露と比較して、損傷レベルは有意に高かった、と報告している。
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To study the effect of CDMA mobile phone signals on DNA integrity in human leukocytes. The effect of aphidicolin on DNA damage induced by radiofrequency signals was also investigated (to study DNA repair efficiency).
Aphidicolin is a compound with anti-mitotic properties and is known as DNA repair inhibitor.
Blood samples were taken from six healthy males.
ばく露時間: continuous for 1 h and 2 h
blood samples were treated in the following ways: i) EMF exposure ii)sham exposure iii) 0.2 µg/ml APC added iv) 2 µg/ml APC added v) 0.2 µg/ml APC added + EMF exposure vi) 2 µg/ml APC added + EMF exposure
|ばく露時間||continuous for 1 h and 2 h|
|Sham exposure||A sham exposure was conducted.|
The data showed that CDMA radiofrequency electromagnetic fields alone did not induce a significant DNA damage in exposed blood samples while in combination with the DNA repair inhibitor aphidicolin the DNA damage was significant. Aphidicolin alone (at 2 µg/ml) also showed significant DNA damage levels when compared to sham exposed samples. DNA repair efficiency also varied in a significant way in combinative exposure sets (2 µg/ml was relatively more effective as DNA repair inhibitor than 0.2 µg/ml).
The data suggest that the DNA repair inhibitor aphidicolin enhances DNA damage at 2 µg/ml and that the damage is possibly repairable. Thus, the in vitro exposure to radiofrequency signals induces reversible DNA damage in synergism with aphidicolin.