研究のタイプ: 医学/生物学の研究 (experimental study)

[CDMA携帯電話からの無線周波信号とアフィジコリンの組み合わせばく露のDNA完全性に対する影響] med./bio.

Combinative Exposure Effect of Radio Frequency Signals from CDMA Mobile Phones and Aphidicolin on DNA Integrity.

掲載誌: Electromagn Biol Med 2008; 27 (4): 418-425

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研究目的(著者による)

To study the effect of CDMA mobile phone signals on DNA integrity in human leukocytes. The effect of aphidicolin on DNA damage induced by radiofrequency signals was also investigated (to study DNA repair efficiency).

詳細情報

Aphidicolin is a compound with anti-mitotic properties and is known as DNA repair inhibitor.
Blood samples were taken from six healthy males.

影響評価項目

ばく露

ばく露 パラメータ
ばく露1: 835 MHz
ばく露時間: continuous for 1 h and 2 h
  • SAR: 1.17 W/kg

General information

blood samples were treated in the following ways: i) EMF exposure ii)sham exposure iii) 0.2 µg/ml APC added iv) 2 µg/ml APC added v) 0.2 µg/ml APC added + EMF exposure vi) 2 µg/ml APC added + EMF exposure

ばく露1

主たる特性
周波数 835 MHz
タイプ
  • electromagnetic field
ばく露時間 continuous for 1 h and 2 h
ばく露装置
ばく露の発生源/構造
  • セルラ-電話
Sham exposure A sham exposure was conducted.
パラメータ
測定量 種別 Method Mass 備考
SAR 1.17 W/kg - - - -

方法 影響評価項目/測定パラメータ/方法

研究対象とした生物試料:
調査の時期:
  • ばく露後

研究の主なアウトカム(著者による)

The data showed that CDMA radiofrequency electromagnetic fields alone did not induce a significant DNA damage in exposed blood samples while in combination with the DNA repair inhibitor aphidicolin the DNA damage was significant. Aphidicolin alone (at 2 µg/ml) also showed significant DNA damage levels when compared to sham exposed samples. DNA repair efficiency also varied in a significant way in combinative exposure sets (2 µg/ml was relatively more effective as DNA repair inhibitor than 0.2 µg/ml).
The data suggest that the DNA repair inhibitor aphidicolin enhances DNA damage at 2 µg/ml and that the damage is possibly repairable. Thus, the in vitro exposure to radiofrequency signals induces reversible DNA damage in synergism with aphidicolin.

研究の種別:

研究助成

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