研究のタイプ: 医学/生物学の研究 (experimental study)

[900MHz GSM変調EMFへの連続的ばく露は神経細胞の形態学的な成熟を変化させる] med./bio.

Continuous exposure to 900MHz GSM-modulated EMF alters morphological maturation of neural cells.

掲載誌: Neurosci Lett 2009; 455 (3): 173-177

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研究目的(著者による)

To study the effects of radiofrequency electromagnetic field exposure on neuronal phenotype maturation in two different in vitro models: murine primary cortical neurons (of rat) and murine cholinergic SN56 cell line.

影響評価項目

ばく露

ばく露 パラメータ
ばく露1: 900 MHz
ばく露時間: 1, 2 or 3 days for SN56 cell line; 1 to 6 days for cortical neurons

ばく露1

主たる特性
周波数 900 MHz
タイプ
  • electromagnetic field
ばく露時間 1, 2 or 3 days for SN56 cell line; 1 to 6 days for cortical neurons
ばく露装置
ばく露の発生源/構造
ばく露装置の詳細 couple of 14 cm wide TEM cells that produce a transverse electromagnetic field
パラメータ
測定量 種別 Method Mass 備考
SAR 1 W/kg - - - -

ばく露を受けた生物:

方法 影響評価項目/測定パラメータ/方法

研究対象とした生物試料:
調査の時期:
  • ばく露中
  • ばく露後

研究の主なアウトカム(著者による)

The data showed that radiofrequency electromagnetic field exposure reduced the number of neurites generated by both cell systems, and this alteration correlates to increased gene expression of beta-thymosin. Gene expression of c-Fos and c-Jun was not affected by exposure. Additionally, neither neurite length nor branching was affected by exposure.
The alteration of beta-thymosin expression by radiofrequency exposure could be a direct or an indirect effect of the irradiation. Further studies are needed (also by means of other exposure schedules) to verify the effects described and to find out the molecular mediators and pathways modifying neural cell phenotype.

研究の種別:

研究助成

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