研究のタイプ: 医学/生物学の研究 (experimental study)

[ラットの精巣機能に対するCDMAおよびWCDMA電磁界への同時複合ばく露の影響] med./bio.

The effects of simultaneous combined exposure to CDMA and WCDMA electromagnetic fields on rat testicular function.

掲載誌: Bioelectromagnetics 2012; 33 (4): 356-364

この論文は、ラット精巣機能のうちでも特に感受性が高いと思われる精子形成過程に対するCDMAおよびWCDMA電磁界への同時複合ばく露の影響を調べた。ばく露は45 分/日、5 日/週で12週間行い、CDMAおよびWCDMAによる全身平均SARはそれぞれ2.0 W/kg で、合計4.0 W/kg であった。このような複合ばく露の結果、ラット精子形成に対する観察可能な有害影響はなかったと結論している。

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研究目的(著者による)

To study the effects of combined exposure to radiofrequency electromagnetic fields (WCDMA and CDMA) on rat testicular function (specifically with respect to spermatogenesis).

詳細情報

50 male rats were used, randomly assigned to four groups: a cage control (n=5), a sham exposed control (n=20), a combined radiofrequency-exposed (n=20) or a gamma ray-exposed group (as positive control, 5 Gy, n= 5).

影響評価項目

ばく露

ばく露 パラメータ
ばく露1: 848.5–1,950 MHz
ばく露時間: continuous 45 min/day, 5 days/week for 12 weeks
  • 電力: 30 W (CDMA)
  • 電力: 18 W (WCDMA)
  • SAR: 2 W/kg average over mass (whole body) (WCDMA)
  • SAR: 2 W/kg average over mass (whole body) (CDMA)
  • SAR: 4 W/kg average over mass (whole body) (total for the combined exposure to CDMA and WCDMA)

General information

rats were treated in four groups: i) cage control ii) sham exposure iii) RF exposure iv) exposure to gamma rays

ばく露1

主たる特性
周波数 848.5–1,950 MHz
タイプ
  • electromagnetic field
ばく露時間 continuous 45 min/day, 5 days/week for 12 weeks
Additional information 848.5 MHZ = CDMA 1950 MHz = WCDMA
ばく露装置
ばく露の発生源/構造
  • antennas connected to a computer
チャンバの詳細 2295 mm x 2293 mm x 1470 mm reverberation chamber with 2.3 mm thick stainless steel walls as exposure chamber
ばく露装置の詳細 five 420 mm x 260 mm x 180 mm polycarbonate cages with two rats each placed inside the reverberation chamber; rats exposed simultaneously to WCDMA and CDMA
Sham exposure A sham exposure was conducted.
パラメータ
測定量 種別 Method Mass 備考
電力 30 W - - - CDMA
電力 18 W - - - WCDMA
SAR 2 W/kg average over mass 計算値 whole body WCDMA
SAR 2 W/kg average over mass 計算値 whole body CDMA
SAR 4 W/kg average over mass 計算値 whole body total for the combined exposure to CDMA and WCDMA

ばく露を受けた生物:

方法 影響評価項目/測定パラメータ/方法

研究対象とした生物試料:
研究対象とした臓器系:
調査の時期:
  • ばく露後

研究の主なアウトカム(著者による)

No significant differences in testicular function, including sperm counts in the cauda epididymis, MDA concentration in testes and epididymis, frequency of spermatogenesis stages, or number of apoptotic cells in each testis, were found during spermatogenesis in rats simultaneously exposed to CDMA and WCDMA radiofrequency electromagnetic fields at a SAR of 2 W/kg each (4 W/kg total) for 12 weeks.
The authors conclude, that the findings suggest that simultaneous exposure to 848.5 MHz and 1950 MHz radiofrequency electromagnetic fields had no adverse effects on the male reproductive system, as seen in this rat spermatogenesis model.

研究の種別:

研究助成

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