研究のタイプ: 医学/生物学の研究 (experimental study)

[従来型携帯電話からの電磁放射で誘発されたラット精巣障害と抗酸化剤であるビタミンCおよびEの保護作用] med./bio.

Rat testicular impairment induced by electromagnetic radiation from a conventional cellular telephone and the protective effects of the antioxidants vitamins C and E.

掲載誌: Clinics (Sao Paulo) 2012; 67 (7): 785-792

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研究目的(著者による)

To investigate the possible effects of exposure from a cellular phone on the oxidant and antioxidant status in blood and testis of rats and to determine the possible protective role of vitamin C and vitamin E.

詳細情報

Six groups were examined: 1.) sham exposure (n=10), 2.) sham exposure + vitamin C (n=10), 3.) sham exposure + vitamin E (n=10), 4.) exposure (n=30), 5.) exposure + vitamin C (n=30) and 6.) exposure + vitamin E (n=30). Animals were exposed for 15, 30 or 60 minutes per day (10 animals, respectively).

影響評価項目

ばく露

ばく露 パラメータ
ばく露1: 900–1,900 MHz
ばく露時間: continuous for 15, 30 or 60 min/day during 14 days

General information

Animals were divided into the following six groups: i) sham exposure ii) sham exposure + daily treatment with 40 mg/kg vitamin C iii) sham exposure + daily treatment with 2.7 mg/kg vitamin E iv) EMF exposure v) EMF exposure + daily treatment with 40 mg/kg vitamin C vi) EMF exposure + daily treatment with 2.7 mg/kg vitamin E

ばく露1

主たる特性
周波数 900–1,900 MHz
タイプ
  • electromagnetic field
ばく露時間 continuous for 15, 30 or 60 min/day during 14 days
ばく露装置
ばく露の発生源/構造
  • GSM mobile phone
Distance between exposed object and exposure source 50 cm
ばく露装置の詳細 rats placed in Plexiglas cages with drilled ventilation holes that were attached to a mobile phone hand set
Sham exposure A sham exposure was conducted.
パラメータ
測定量 種別 Method Mass 備考
電力 2 W peak - - -
電力密度 0.02 mW/cm² average over time - - -
SAR 0.9 W/kg - - - -

ばく露を受けた生物:

方法 影響評価項目/測定パラメータ/方法

研究対象とした生物試料:
研究対象とした臓器系:
調査の時期:
  • ばく露後

研究の主なアウトカム(著者による)

In the histopathological examination, the testis of sham exposed rats showed normal seminiferous tubules, spermatids and spermatogenic cells. However, the testis of exposed rats showed significant degenerative changes: An increased diameter of the seminiferous tubules, a decreased mean height of the germinal epithelium, a reduction of the spermatid number, big nuclei (karyomegaly), a high incidence of mitotic divisions and pyknosis of some spermatogonial nuclei. An administration of vitamin C or E caused a significant decrease of the exposure induced effects.
In all exposure groups, in the blood serum and in the testis, the amount of glutathione and the enzyme activity of the glutathione peroxidase were significantly decreased (stronger decrease with increasing exposure duration) compared with the control group, whereas the levels of the lipid peroxidation and the enzyme activity of the catalase were significantly increased (stronger increase with increasing exposure duration). An administration of vitamin C or vitamin E blocked the exposure induced effects (Remark EMF-Portal: results taken from table, partially contradictory results in running text).
The author concludes that exposure to an electromagnetic field could have a negative effect on testicular function through the induction of oxidative stress. The results also indicate a protective effect of vitamin C and vitamin E.

研究の種別:

研究助成

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