研究のタイプ: 医学/生物学の研究 (experimental study)

[超低周波磁界ばく露はアルミニウム過剰投与ラットのアルツハイマー病発病に影響しないようである] med./bio.

Extremely low-frequency magnetic exposure appears to have no effect on pathogenesis of Alzheimer's disease in aluminum-overloaded rat.

掲載誌: PLoS One 2013; 8 (8): e71087-1-e71087-8

この研究は、超低周波磁界(ELF-MF:50 Hz、100 μT)とアルミニウム(Al)のアルツハイマー病(AD)発病への相乗効果の有無を調べた。成獣のSD雄ラットを10匹ずつの4群に分けた。対照群擬似ばく露)、Al群(Alの経口摂取)、MF+Al群(ELF-MFばく露+Alの経口摂取)、MF単独群(ELF-MFばく露のみ)である。Al経口摂取はAl含有飲料水の自由摂取により、ELF-MFばく露ヘルムホルツコイルにより、1日24時間、12週間連続ばく露した。ばく露終了後、行動テストおよび海馬大脳皮質組織検査を行った。その結果、Al群、MF+Al群では、学習記憶の障害、海馬大脳皮質組織での神経細胞脱落やアミロイドβ沈着が見られた;MF単独群はAD発症への有意な影響を示さなかった;Al群よりMF+Al群の方が損傷の程度が低かった、と報告している。

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研究目的(著者による)

To study whether or not an extremely low-frequency magnetic field exposure and aluminium treatment have synergistic effects on Alzheimer's disease pathogenesis by investigating the effects of extremely low-frequency magnetic field exposure with or without chronic aluminium treatment in rats.

詳細情報

Rats were divided into the following groups (each group n=10): 1.) sham exposure, 2.) oral aluminium administration, 3.) magnetic field exposure with oral aluminium administration, or 4.) magnetic field exposure without oral aluminium administration. The experiments were repeated three times.

影響評価項目

ばく露

ばく露 パラメータ
ばく露1: 50 Hz
ばく露時間: continuous for 12 weeks

General information

Rats of the control groups were placed in a geomagnetic environment (ambient magnetic field (50 Hz) <400 nT; geomagnetic field 9-32 µT)

ばく露1

主たる特性
周波数 50 Hz
タイプ
  • magnetic field
ばく露時間 continuous for 12 weeks
ばく露装置
ばく露の発生源/構造
チャンバの詳細 rats were housed in plastic cages
ばく露装置の詳細 pair of Helmholtz coils (diameter: 1400 mm); rats placed in the center of the coils; magnetic field direction was vertical; room temperature 23±1°C
パラメータ
測定量 種別 Method Mass 備考
磁束密度 100 µT - - - -

ばく露を受けた生物:

方法 影響評価項目/測定パラメータ/方法

研究対象とした生物試料:
研究対象とした臓器系:
調査の時期:
  • ばく露中
  • ばく露後

研究の主なアウトカム(著者による)

After 12 weeks, aluminium groups (groups 2 and 3) showed learning and memory impairments as well as morphological changes in the brain, including neuronal cell loss and a high density of beta-amyloid protein in the hippocampus and cerebral cortex. Extremely low-frequency magnetic exposure alone (group 4) showed no significant effect on Alzheimer's disease pathogenesis. Co-exposure of extremely low-frequency magnetic field and aluminium (group 3) did not induce more damage than aluminium treatment alone (group 2).
The data showed no evidence of any association between extremely low-frequency magnetic exposure exposure (100 µT, 50 Hz) and Alzheimer's disease, and extremely low-frequency magnetic field exposure did not influence the pathogenesis of Alzheimer's disease induced by aluminium overload.

研究の種別:

研究助成

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