この研究は、ラットの電気ショック誘導による攻撃性に対するGABAB受容体と超低周波電磁界（ELF-EMF：50 Hz、500 µT）の相互作用的影響を調べた。SD雄ラット（n=50）を無作為に10群、すなわちELF-EMFばく露の有無と5種類の物質投与（生食、CGP35348（GABAB作動薬）およびBaclofen（GABAB拮抗薬）の低濃度および高濃度）の組み合わせに分けた。ELF-EMFばく露（擬似ばく露）を1日8時間、30日間行った後に、それぞれの物質投与を行い、その20分後に足に電気ショックを与えて誘発させた攻撃性行動（立ち上がり威嚇、噛み、追跡、接近など）の観察数を記録した。その結果、ELF-EMF・Baclofen・CGP35348単独群では有意な影響は観察されなかった；ELF-EMFばく露とCGP35348およびBaclofenの組み合わせ群では、高低どちらの濃度でも有意な影響は見られなかった、と報告している。
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Aggression constitutes a serious clinical and social problem. Neurotransmitters such as gamma aminobutyric acid (GABA) play a key role in modulation of aggression in all mammalian species. On the other hand, strong magnetic fields may influence the central nervous system. Therefore, the possible correlation of magnetic field exposure and aggression as well as the role of GABAB receptors should be investigated.
10 groups of rats were examined (n= 5 per group): 1.) sham exposure + saline, 2.) exposure + saline, 3.) sham exposure + 100 mg of the GABAB antagonist CGP35348 per kg body weight, 4.) exposure + 100 mg/kg of CGP35348, 5.) sham exposure + 200 mg/kg CGP35348, 6.) exposure + 200 mg/kg CGP35348, 7.) sham exposure + 1.7 mg of the GABAB agonist baclofen per kg body weight, 8.) exposure + 1.7 mg/kg baclofen, 9.) sham exposure + 3 mg/kg baclofen and 10.) exposure + 3 mg/kg baclofen. After the exposure period, rats received the substances via intraperitoneal injection and were tested for aggression behavior for 20 minutes.
ばく露時間: continuous for 8 h/day for 30 days
|ばく露時間||continuous for 8 h/day for 30 days|
|ばく露装置の詳細||the magnetic field chamber consisted of a 70 x 120 x 30 cm wooden cage; three coils of electrically insulated 1 mm copper wire with 200 turns each were wound around the outer surface at equal distance; coils were connected in parallel and sealed with adhesive bandage; electrical source was an autotransformer with the input of 50 Hz and 220 V; field was homogeneous in a zone of 21 cm distance from the transverse borders and 9 cm from the longitudinal borders|
|Sham exposure||A sham exposure was conducted.|
No significant differences were observed between magnetic field exposed (group 2) and sham exposed rats (group 1). Only rats exposed to magnetic fields and treated with 100 mg/kg CGP35348 (group 4) showed a significantly increased number of "lifted up threats" compared to magnetic field exposed rats with saline injection (group 2) and compared to sham exposed rats with 100 mg CGP35348 (group 3).
The authors conclude that extremely low frequency magnetic fields alone or in combination with a GABAB-agonist or -antagonist have no influence on the aggression behavior of rats in the used aggression model.