研究のタイプ: 医学/生物学の研究 (experimental study)

[超低周波磁界は神経伝達物質のレベルを変化させる] med./bio.

Extremely low frequency magnetic field modulates the level of neurotransmitters.

掲載誌: Korean J Physiol Pharmacol 2015; 19 (1): 15-20

この研究は、超低周波磁界(ELF-MF;60Hz、2.0mT)に2または5日間ばく露させたラットの脳の皮質線条体視床小脳海馬における生体アミンとその代謝アミノ酸神経伝達物質一酸化窒素NO)を調べた。その結果、ELF-MFばく露群で、線条体視床小脳海馬におけるノルエピネフリンとバニリルマンデル酸に有意差が見られた;また線条体視床海馬でセレトニンと5ヒドロキシインドール酸のレベルが有意に上昇した、などいくつかの観察結果を報告している。

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研究目的(著者による)

The effects of a whole body exposure of rats to a 60 Hz magnetic field on the level of various neurotransmitters and nitric oxide in the brain should be investigated.

詳細情報

30 rats were divided into the following groups (n=10 each): 1) sham exposure, 2) exposure for 2 days and 3) exposure for 5 days.

影響評価項目

ばく露

ばく露 パラメータ
ばく露1: 60 Hz
ばく露時間: continuous for 2 days
  • 磁束密度: 2 mT effective value (at the center of the cage)
  • 磁束密度: 1.8 mT effective value (at the edges of the cage)
ばく露2: 60 Hz
ばく露時間: continuous for 5 days
  • 磁束密度: 2 mT effective value (at the center of the cage)
  • 磁束密度: 1.8 mT effective value (at the edges of the cage)

ばく露1

主たる特性
周波数 60 Hz
タイプ
  • magnetic field
ばく露時間 continuous for 2 days
ばく露装置
ばく露の発生源/構造
ばく露装置の詳細 a pair of Helmholtz coils embedded in an open rectangular frame (140x85x70 cm3), with each coil having 200 turns of an insulated soft copper wire with a diameter of 1 mm; each winding was split, allowing the current to flow in the same direction through each half of the winding (field adding); non-magnetic cage was placed at the center; temperature was 25±2°C
Sham exposure A sham exposure was conducted.
パラメータ
測定量 種別 Method Mass 備考
磁束密度 2 mT effective value 測定値 - at the center of the cage
磁束密度 1.8 mT effective value 測定値 - at the edges of the cage

ばく露2

主たる特性
周波数 60 Hz
タイプ
  • magnetic field
ばく露時間 continuous for 5 days
ばく露装置
ばく露の発生源/構造
  • E1と同じ装置
パラメータ
測定量 種別 Method Mass 備考
磁束密度 2 mT effective value 測定値 - at the center of the cage
磁束密度 1.8 mT effective value 測定値 - at the edges of the cage

ばく露を受けた生物:

方法 影響評価項目/測定パラメータ/方法

研究対象とした生物試料:
研究対象とした臓器系:
調査の時期:
  • ばく露後

研究の主なアウトカム(著者による)

Regarding the biogenic amine neurotransmitters, the level of norepinephrine was significantly decreased and the level of vanillylmandelic acid was significantly increased in all brain regions except for the cortex in both exposure groups compared to the sham exposure. The level of serotonin was significantly increased in group 3 (5 days exposure) in the striatum and thalamus compared to sham exposure. The level of 5-hydroxyindoleacetic acid was significantly increased in the striatum and hippocampus in group 3 and in the thalamus in groups 2 (2 days exposure) and 3 compared to sham exposure. The dopamine level was significantly increased in the thalamus in group 3 compared to sham exposure.
The following amino acid neurotransmitters levels showed significant alterations in the named brain regions in group 3 compared to sham exposure: aspartic acid decreased in the cortex, glutamate increased in the thalamus, glutamine decreased in the cortex and cerebellum and increased in the striatum and thalamus, glycine decreased in the cortex and hippocampus and increased in the striatum and thalamus, taurine decreased in the cortex and hippocampus, tyrosine increased in the thalamus and gamma aminobutyric acid decreased in the cortex, cerebellum and hippocampus and increased in the striatum and thalamus.
The nitric oxide level was significantly increased in the striatum in groups 2 and 3 and additionally in the thalamus and hippocampus solely in group 3 compared to sham exposure.
The authors conclude that an exposure of rats to a 60 Hz magnetic field could change the level of various neurotransmitters and nitric oxide in the brain.

研究の種別:

研究助成

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