研究のタイプ: 疫学研究 (observational study)

[オランダの前向きコホート調査における職業ばく露と認知症関連の死亡リスク] epidem.

Occupational exposures and risk of dementia-related mortality in the prospective Netherlands Cohort Study.

掲載誌: Am J Ind Med 2015; 58 (6): 625-635

この研究は、オランダの前向きコホート調査において、職業ばく露(調査した因子:溶剤、殺虫剤、金属、超低周波磁界(ELF-MF)、電撃、ジーゼル車排気ガス)が非血管認知症に関連した死亡リスクに及ぼす影響を分析した。各種の職業ばく露の割り当てには職種ばく露マトリクスを用いた。17.3年間の追跡期間を経て、男性682人、女性870人の症例が得られた。コックスの回帰モデルを用いて分析した。その結果、金属、塩素系溶剤EMF-MFが、男性の非血管認知症と正の関連性示したことなどを報告している。

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研究の目的(著者による)

The association between the occupational exposure to extremely low-frequency magnetic fields, electrical shocks as well as other risk factors and the risk of dementia-related mortality was investigated in the Netherlands Cohort Study. Furthermore, the effects of combined exposure to these occupational agents were studied.

詳細情報

Following a case-cohort approach, a randomly selected subcohort (n=5000) was drawn.

影響評価項目/リスク推定のタイプ

リスク推定のタイプ: (hazard ratio)

ばく露

ばく露評価

ばく露集団

グループ 説明
参照集団 1 magnetic field exposure: background
集団 2 magnetic field exposure: low
集団 3 magnetic field exposure: high
参照集団 4 magnetic field exposure: background
集団 5 magnetic field exposure: 1st terzile
集団 6 magnetic field exposure: 2nd terzile
集団 7 magnetic field exposure: 3rd terzile
参照集団 8 electric shock risk: background
集団 9 electric shock risk: low
集団 10 electric shock risk: high

調査対象集団

調査規模

タイプ
合計 120,852
その他:

17.3 years of follow-up

統計学的分析方法: ( 調整: )

結論(著者による)

A statistically non-significant association between high occupational exposure to extremely low-frequency magnetic fields and dementia-related mortality was observed in men (OR 1.40, CI 0.92-2.14), but not with cumulative occupational exposure.
A significant association between electrical shocks and dementia-related mortality in women was found (OR 11.11, CI 3.84-32.16). However, this association was only observed among women, and the number of high exposed female cases was very low (approximately 1 % of all female cases). Hence this observation should be interpreted with caution.
The authors conclude that there is only limited support for a possible association between occupational exposure to extremely low-frequency magnetic fields and non-vascular dementia.

研究助成

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