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The association between the occupational exposure to extremely low-frequency magnetic fields, electrical shocks as well as other risk factors and the risk of dementia-related mortality was investigated in the Netherlands Cohort Study. Furthermore, the effects of combined exposure to these occupational agents were studied.
Following a case-cohort approach, a randomly selected subcohort (n=5000) was drawn.
|参照集団 1||magnetic field exposure: background|
|集団 2||magnetic field exposure: low|
|集団 3||magnetic field exposure: high|
|参照集団 4||magnetic field exposure: background|
|集団 5||magnetic field exposure: 1st terzile|
|集団 6||magnetic field exposure: 2nd terzile|
|集団 7||magnetic field exposure: 3rd terzile|
|参照集団 8||electric shock risk: background|
|集団 9||electric shock risk: low|
|集団 10||electric shock risk: high|
17.3 years of follow-up
A statistically non-significant association between high occupational exposure to extremely low-frequency magnetic fields and dementia-related mortality was observed in men (OR 1.40, CI 0.92-2.14), but not with cumulative occupational exposure.
A significant association between electrical shocks and dementia-related mortality in women was found (OR 11.11, CI 3.84-32.16). However, this association was only observed among women, and the number of high exposed female cases was very low (approximately 1 % of all female cases). Hence this observation should be interpreted with caution.
The authors conclude that there is only limited support for a possible association between occupational exposure to extremely low-frequency magnetic fields and non-vascular dementia.