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The effects of exposure of rats to 50 Hz magnetic fields on serum cytokine levels and expression of immune system related genes should be investigated.
A total of 80 rats was divided into the following groups (groups sizes not mentioned): exposure to a magnetic field of 1) 1 µT, 2) 100 µT, 3) 500 µT, 4) 2000 µT and 5) control group. Blood was drawn from all animals for the first time after the first month of exposure (pre-immunization phase). Then animals were injected with human serum albumin three times over the course of the second month to stimulate the immune system. At the end of exposure (after 2 months; post-immunization phase), all animals were killed, the second blood sample was drawn and spleens were removed.
免疫系への影響: serum cytokine levels and expression of immune system related genes
exposure system consisted of solenoids (lengths 2 m, internal diameters 40 cm) coiled with different turns of copper wires (diameter 2 mm) around polyvinyl chloride cylinders; the combination of different turns of wires with different electrical potential in each solenoid produced a different magnetic flux density for each exposure group
免疫系への影響: serum levels of inflammatory cytokines IL-1β and IL-23 (ELISA) and gene expression of genes related to humoral immunity in the spleen (B lymphocyte-induced maturation protein-1 (BLIMP-1), X-box-binding protein-1 (XBP-1) and interferon regulatory factor-4 (IRF-4)) (only post-immunization phase; quantitative RT-PCR)
Serum level of IL-1β was significantly decreased in groups 1 and 2 (1 µT and 100 µT) at pre-immunization phase compared to the control group, whereas IL-23 level was significantly increased in group 2 at post-immunization phase compared to the control group. No significant differences were observed among IL-1 β and IL-23 between post- and pre-immunization phases in any group. The expression levels of BLIMP-1, XBP-1 and IRF-4 were significantly decreased in group 2 compared to the control group at post-immunization phase. The authors conclude that exposure of rats to a weak 50 Hz magnetic field (100 µT) may decrease inflammation and immune response after short exposure durations and increase it after longer durations.