研究のタイプ: 医学/生物学の研究 (experimental study)

Effect of 50-Hz Magnetic Fields on Serum IL-1β and IL-23 and Expression of BLIMP-1, XBP-1, and IRF-4. med./bio.

掲載誌: Inflammation 2019 [in press]

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研究目的(著者による)

The effects of exposure of rats to 50 Hz magnetic fields on serum cytokine levels and expression of immune system related genes should be investigated.

詳細情報

A total of 80 rats was divided into the following groups (groups sizes not mentioned): exposure to a magnetic field of 1) 1 µT, 2) 100 µT, 3) 500 µT, 4) 2000 µT and 5) control group. Blood was drawn from all animals for the first time after the first month of exposure (pre-immunization phase). Then animals were injected with human serum albumin three times over the course of the second month to stimulate the immune system. At the end of exposure (after 2 months; post-immunization phase), all animals were killed, the second blood sample was drawn and spleens were removed.

影響評価項目

ばく露

ばく露 パラメータ
ばく露1: 50 Hz
ばく露時間: 2 hours/day for 2 months
ばく露2: 50 Hz
ばく露時間: 2 hours/day for 2 months
ばく露3: 50 Hz
ばく露時間: 2 hours/day for 2 months
ばく露4: 50 Hz
ばく露時間: 2 hours/day for 2 months

ばく露1

主たる特性
周波数 50 Hz
タイプ
  • magnetic field
ばく露時間 2 hours/day for 2 months
ばく露装置
ばく露の発生源/構造
ばく露装置の詳細 exposure system consisted of solenoids (lengths 2 m, internal diameters 40 cm) coiled with different turns of copper wires (diameter 2 mm) around polyvinyl chloride cylinders; the combination of different turns of wires with different electrical potential in each solenoid produced a different magnetic flux density for each exposure group
Sham exposure A sham exposure was conducted.
パラメータ
測定量 種別 Method Mass 備考
磁束密度 1 µT - 測定値 - -

ばく露2

主たる特性
周波数 50 Hz
タイプ
  • magnetic field
ばく露時間 2 hours/day for 2 months
ばく露装置
ばく露の発生源/構造
  • E1と同じ装置
パラメータ
測定量 種別 Method Mass 備考
磁束密度 100 µT - 測定値 - -

ばく露3

主たる特性
周波数 50 Hz
タイプ
  • magnetic field
ばく露時間 2 hours/day for 2 months
ばく露装置
ばく露の発生源/構造
  • E1と同じ装置
パラメータ
測定量 種別 Method Mass 備考
磁束密度 500 µT - 測定値 - -

ばく露4

主たる特性
周波数 50 Hz
タイプ
  • magnetic field
ばく露時間 2 hours/day for 2 months
ばく露装置
ばく露の発生源/構造
  • E1と同じ装置
パラメータ
測定量 種別 Method Mass 備考
磁束密度 2,000 µT - 測定値 - -

Reference articles

  • Mahdavinejad L et al. (2018): [超低周波電磁界は脾臓におけるインターロイキン-17、形質転換成長因子-βの血清レベルを低下させ、Foxp3発現を下方制御する]
  • Salehi I et al. (2013): [ラットの超低周波電磁界ばく露はサイトカイン産出を変化させる]

ばく露を受けた生物:

方法 影響評価項目/測定パラメータ/方法

研究対象とした生物試料:
調査の時期:
  • ばく露後

研究の主なアウトカム(著者による)

Serum level of IL-1β was significantly decreased in groups 1 and 2 (1 µT and 100 µT) at pre-immunization phase compared to the control group, whereas IL-23 level was significantly increased in group 2 at post-immunization phase compared to the control group. No significant differences were observed among IL-1 β and IL-23 between post- and pre-immunization phases in any group.
The expression levels of BLIMP-1, XBP-1 and IRF-4 were significantly decreased in group 2 compared to the control group at post-immunization phase.
The authors conclude that exposure of rats to a weak 50 Hz magnetic field (100 µT) may decrease inflammation and immune response after short exposure durations and increase it after longer durations.

研究の種別:

研究助成

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