研究のタイプ: 医学／生物学の研究 (experimental study)

[麻酔されたラットでの5.6 GHz無線周波放射に対する体温反応：クロルプロマジンの影響] med./bio.

Thermal responses to 5.6-GHz radiofrequency radiation in anesthetized rats: effect of chlorpromazine

著者: Jauchem JR, Frei MR, Heinmets F
掲載誌: Physiol Chem Phys Med NMR 1988; 20 (2): 135-143
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この研究は、麻酔処置されたラットに、平均電力密度60 mW / cm 2（平均比吸収率12 W / kg）の5.6 GHzの連続波の無線周波電磁放射（RFR）ばく露を実施した。結腸温度を38.5℃から39.5℃に上昇させるようばく露した場合、クロルプロマジンの急性投与により、ばく露中断時のベースライン体温への復帰は早まった；ばく露を38.5℃で開始し、致死温度に達するまで続けた場合、クロルプロマジン投与ラットは食塩水投与ラットよりも生存期間が有意に短くなった；以上から、クロルプロマジンは、39.5℃以下の結腸温度で体温調節効率を高め、致死的なRFRばく露に対する感受性を増強した；2.8 GHzを用いた先行研究と比較すると、クロルプロマジンの効果は、2.8 GHzおよび5.6 GHzで同様であった、と報告している。

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研究目的（著者による）

To determine if chlorpromazine affects the thermal responses, heart rate, blood pressure, and respiratory rate of anesthetized rats during exposure to 5.6 GHz radiofrequency irradiation (this frequency is characteristic of high-power stationary tracking radars for military applications and of naval ship radars).

詳細情報

Experiments were performed that resulted in two stages: 1) exposures were performed that resulted in colonic temperture increase from 38.5 to 39.5°C, and 2) radiofrequency irradiation was initiated at 38.5°C and continued until death body temperatures were attained.

影響評価項目

ばく露

ばく露 パラメータ
ばく露1: 5.6 GHz
Modulation type: CW
ばく露時間: until temperature rise of 1°C
  • 電力密度: 60 mW/cm² average over time
  • SAR: 12 W/kg average over time (whole body)
ばく露2: 5.6 GHz
Modulation type: CW
ばく露時間: until lethal colonic temperature; 29.5 +/- 2.6 min without saline treatment; 36.9 +/- 2.2 min saline-treated
  • 電力密度: 60 mW/cm² average over time
  • SAR: 12 W/kg average over mass (whole body)

ばく露1

主たる特性
周波数 5.6 GHz
タイプ
  • electromagnetic field
特性
  • far field
ばく露時間 until temperature rise of 1°C
Additional information exposure started at a colonic temperature of 38.5°C; exposure was discontinued when the colonic temperature increased to 39.5°C and it was initiated again when the temperature returned to 38.5°C; this procedure was continued for 6 cycles (drugs were administered before the 4th cycle).
Modulation
Modulation type CW
ばく露装置
ばく露の発生源／構造
ばく露装置の詳細 long axis of animal parallel to the magnetic field
パラメータ
測定量 値 種別 Method Mass 備考
電力密度 60 mW/cm² average over time 測定値 - -
SAR 12 W/kg average over time 計算値 whole body -

ばく露2

主たる特性
周波数 5.6 GHz
タイプ
  • electromagnetic field
特性
  • far field
ばく露時間 until lethal colonic temperature; 29.5 +/- 2.6 min without saline treatment; 36.9 +/- 2.2 min saline-treated
Modulation
Modulation type CW
ばく露装置
ばく露の発生源／構造
  • E1と同じ装置
パラメータ
測定量 値 種別 Method Mass 備考
電力密度 60 mW/cm² average over time 測定値 - -
SAR 12 W/kg average over mass 計算値 whole body -

ばく露を受けた生物:

方法 影響評価項目／測定パラメータ／方法

研究対象とした生物試料:
研究対象とした臓器系:
調査の時期:
  • ばく露中

研究の主なアウトカム（著者による）

After acute administration of chlorpromazine, body temperature exhibited a faster return to baseline temperature when irradiation was discontinued. When irradiation was initiated at 38.5°C and continued until lethal temperatures resulted, chlorpromazine-treated rats exhibited significantly shorter survival times than saline-treated rats. Thus, although chlorpromazine enhanced thermoregulatory efficiency at colonic temperatures below 39.5°C, the drug produced increased susceptibility to terminal radiofrequency irradiation.
The present findings, when compared to previous studies of irradiation at 2.8 GHz (e.g. publication 4486), suggest that the effects of chlorpromazine on thermal responses to radiofrequency irradiation during intermittent and terminal exposure are similar at both 2.8 and 5.6 GHz.

研究の種別:

研究助成

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