Coombs' test

  • antiglobulin test
German: Coombs Test
Japanese: クームス試験

Immunology. Named after Robin Coombs, born 1921. An immunological laboratory test to detect incomplete antibodies coating erythrocytes. In the direct Coombs test, red blood cells, taken directly from a sensitized individual, are agglutinated by antigammaglobulin antibodies (e.g., in haemolytic disease of newborn and autoimmune haemolytic anaemia). In the indirect Coombs test, a patients serum is incubated with test red blood cells to detect circulating antibodies.

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