This study was performed to investigate the effects of magnetic field shielding on analgesia in mice.
Three objectives were targeted: 1) Whether a daily 1 h magnetic field shielding, repeated on 10 consecutive days affect analgesia in mice. 2) If possible shielding effects depend rather on magnetic field than on ambient electric field. 3) To determine if possible shielding effects are consistent with opioid mediated analgesia.
The magnetic field shielding was achieved by the use of special Mu-metal (TM) material.
Exposure duration: repeated daily exposure, 1 h/day for 10 consecutive days
|Exposure room||Mu-metal enclosures (33 x 38 x 20 cm³) made of 1 mm Mu metal and laminated with 5 mm thick opaque Plexiglas|
|Setup||mice were placed individually in a translucent acrylic cage (26 x 16 x 12 cm³) which was placed in the Mu-metal enclosure|
|Sham exposure||A sham exposure was conducted.|
|Additional info||The sham enclosures (33 x 38 x 20 cm) were made of 5 mm thick black opaque Plexiglas. Acrylic mouse colony cages were used for holding individual mice inside sham enclosures.|
A robust effect on analgesia depending on magnetic field shielding was observed. The maximum analgesic response occured over days 4-6 of the experiment. The effect seems to be opioid related as indicated by experiments using morphine and naloxone.