To investigate whether magnetic field exposure is capable to act as a tumor promotor in the DMBA/TPA induced skin tumor model in mice.
An single DMBA dose (25.6 µg) was applied to the skin to initiate tumor development. 8 days thereafter TPA (3.08 µg) was applied twice weekly to promote tumor development, and magnetic field exposure (50 µT or 0.5 mT) was started. Animals were examined after 9, 26, 52 and 103 weeks of magnetic field exposure.
| Exposure | Parameters |
|---|---|
|
Exposure 1:
50 Hz
Exposure duration:
repeated daily exposure, 21 h/day für 103 weeks
|
|
| Frequency | 50 Hz |
|---|---|
| Type | |
| Waveform | |
| Exposure duration | repeated daily exposure, 21 h/day für 103 weeks |
| Exposure source |
|
|---|
| Measurand | Value | Type | Method | Mass | Remarks |
|---|---|---|---|---|---|
| magnetic flux density | 50 µT | - | measured | - | - |
| magnetic flux density | 500 µT | - | measured | - | - |
No statistically significant differences in mortality, epidermal thickness (hyperplasia), skin tumor orcurrence, and skin histopathology could be found between the control and the magnetic field exposed groups.
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