Study type: Medical/biological study (experimental study)

B16 melanoma development in black mice exposed to low-level microwave radiation med./bio.

By: Santini R, Hosni M, Deschaux P, Pacheco H
Published in: Bioelectromagnetics 1988; 9 (1): 105-107
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Aim of study (acc. to author)

To determine if prior low-level microwave exposition (continuous waves or pulsed waves) has any effect on the development of B16 melanoma or survival times in black mice.

Background/further details

Melanoma cells were subcutaneously implanted in mice.

Endpoint

Exposure

Exposure Parameters
Exposure 1: 2.45 GHz
Modulation type: CW
Exposure duration: 2.5 h/day, 6 times/week, upto 690 h
Exposure 2: 2.45 GHz
Modulation type: pulsed
Exposure duration: 2.5 h/day, 6 times/week, upto 690 h

General information

Mice were randomly assigned into three groups (n=15/group): Control group, CW (continuous wave) group (E1) and PW (pulsed wave) group (E2).

Exposure 1

Main characteristics
Frequency 2.45 GHz
Type
Charakteristic
Polarization
Exposure duration 2.5 h/day, 6 times/week, upto 690 h
Modulation
Modulation type CW
Exposure setup
Exposure source
  • not specified
Chamber Anechoic chamber/170 cm long, 60 cm wide and 105 cm high
Setup Animals placed in a polystyrene cage (25 cm long, 16 cm wide and 13 cm high) with the electric field parallel to the length of the cage.
Additional info Control mice were placed in the anechoic chamber in the same cages as exposed ones for the same amount of time without microwave exposure.
Parameters
Measurand Value Type Method Mass Remarks
power density 10 W/m² unspecified measured - -
SAR 1.2 mW/g unspecified unspecified unspecified -

Exposure 2

Main characteristics
Frequency 2.45 GHz
Type
Charakteristic
Polarization
Exposure duration 2.5 h/day, 6 times/week, upto 690 h
Modulation
Modulation type pulsed
Additional info

10 ms duration of a burst of spikes, 30 ms between 2 bursts of spikes, 10 µs spike duration, 5 µs between 2 spikes.
Exposure setup
Exposure source
Parameters
Measurand Value Type Method Mass Remarks
power density 10 W/m² unspecified measured - -
SAR 1.2 mW/g unspecified unspecified unspecified -

Exposed system:

Methods Endpoint/measurement parameters/methodology

Investigated system:
Investigated organ system:
Time of investigation:
  • during exposure

Main outcome of study (acc. to author)

No significant effects are observed on tumor development or on survival times compared to controls, or between CW- and PW-treated mice.

Study character:

Study funded by