Study type: Medical/biological study (experimental study)

Effect of Lycopersicon esculentum extract on apoptosis in the rat cerebellum, following prenatal and postnatal exposure to an electromagnetic field. med./bio.

Published in: Exp Ther Med 2013; 6 (1): 52-56

Aim of study (acc. to author)

To examine the effects of prenatal und postnatal exposure to electromagnetic fields on the rat cerebellum and the potential protective effect of Lycopersicon esculentum (tomato).

Background/further details

Three groups of rats were examined: 1.) control group, 2.) exposure and 3.) exposure + tomato extract (2g/kg/day).

Endpoint

Exposure

Exposure Parameters
Exposure 1: 900 MHz
Exposure duration: 30 min/day until rats were 80 days old
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Exposure 1

Main characteristics
Frequency 900 MHz
Type
Exposure duration 30 min/day until rats were 80 days old
Exposure setup
Exposure source
Parameters

No parameters are specified for this exposure.

Exposed system:

Methods Endpoint/measurement parameters/methodology

Investigated system:

Main outcome of study (acc. to author)

So-called "dark neurons" were found in both exposed groups. However, less were present in the third group with tomato extract. No dark neurons were found in the control group.
The number of caspase-3-positive Purkinje cells and granule cells was significantly increased in the exposed group compared to the control group where no caspase-3-positive cells were detected. An administration of tomato extract attenuated this effect and significantly decreased the number of caspase-3-positive Purkinje cells and granule cells.
The authors conclude that prenatal und postnatal exposure to electromagnetic fields could induce apoptosis and neurodegeneration in the rat cerebellum and that tomato extract could prevent this effect.

Study character:

Study funded by