The authors investigated the effect of pretreatment with the narcotic antagonist naltrexone on microwave-induced changes in muscarinic cholinergic receptors. Because the acute effect can be blocked by naltrexone, it is expected that the neurological consequences of repeated irradiation (i.e. changes in neurotransmitter receptor concentrations) also can be blocked.
|Pulse width||2 µs|
|Repetition frequency||500 Hz|
Repeated irradiation of rats to pulsed microwaves induced biphasic changes in the concentration of muscarinic cholinergic receptors in the CNS: An increase in receptor concentration occured in the hippocampus of rats subjected to ten 45-min sessions of microwave exposure, whereas a decrease in receptor concentration was observed in the frontal cortex and hippocampus of animals exposed to ten 20-min sessions. The drug pretreatment blocked the microwave-induced changes in cholinergic receptors in the brain.
The results support the author's hypothesis that endogenous opioids play a role in the effects of microwaves on central cholinergic systems.