Study type: Medical/biological study (experimental study)

Interaction of ethanol and microwaves on the blood-brain barrier of rats. med./bio.

Published in: Bioelectromagnetics 1986; 7 (4): 405-414

Aim of study (acc. to author)

To examine the interaction of microwave irradiation and ethanol as they affect the blood-brain barrier: 1) how varying concentrations of ethanol alter the microwave-induced changes of the barrier's permeability to Evans blue, and 2) how ethanol affect temperature changes in the brain of microwave-exposed animals.

Endpoint

Exposure

Exposure Parameters
Exposure 1: 3.15 GHz
Modulation type: CW
Exposure duration: continuous for 15 min

Exposure 1

Main characteristics
Frequency 3.15 GHz
Type
Waveform
Polarization
Exposure duration continuous for 15 min
Modulation
Modulation type CW
Exposure setup
Exposure source
  • coaxial applicator, flat surface 7 mm radius
Setup animal was placed in a stereotaxic apparaturswith the microwave applicator was placed in firm contact with the dorsal surface of the animal`s head
Parameters
Measurand Value Type Method Mass Remarks
power density 3 W/cm² effective value calculated - -

Exposed system:

Methods Endpoint/measurement parameters/methodology

Investigated system:
Investigated organ system:
Time of investigation:
  • during exposure
  • after exposure

Main outcome of study (acc. to author)

Irradiation of rats by 3.15 GHz continuos wave microwaves can produce intense hyperthermia and alteration of the permeability of the blood-brain barrier. This hyperthermia and change in permeability is diminished if rats are given intravenous doses of ethanol prior to irradiation. The results indicate that ethanol inhibits microwave-induced permeation of the blood-brain barrier through reduced heating of the brain.

Study character:

Study funded by