Study type: Medical/biological study (experimental study)

[The influence of radiofrequency electromagnetic fields on the cell cycle and the frequency of sister chromatid exchanges: analyses of human lymphocytes in culture] med./bio.

Der Einfluß von hochfrequenten elektromagnetischen Feldern auf den Zellzyklus und auf die Frequenz von Schwesterchromatidaustauschen: Analysen an menschlichen Lymphozyten in Kultur

By: Antonopoulos A, Obe G, Brinkmann K, Eisenbrandt H, Grigat JP, Elsner R, Storbeck W, Dehmel G
Published in: Edition Wissenschaft 1998; 14: 3-13
Journal not peer-reviewed
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Aim of study (acc. to author)

To investigate the velocity of cell cycle and the frequency of sister-chromatid exchange in cultured lymphocytes exposed to high frequency electromagnetic fields.

Endpoint

Exposure

Exposure Parameters
Exposure 1: 1,800 MHz
Modulation type: pulsed
Exposure duration: continuous for 48, 52, 56, 64, and 68 h
Exposure 2: 900 MHz
Modulation type: pulsed
Exposure duration: continuous for 48, 52, 56, 64, and 68 h
Exposure 3: 380 MHz
Modulation type: pulsed
Exposure duration: continuous for 48, 52, 56, 64, and 68 h

Exposure 1

Main characteristics
Frequency 1,800 MHz
Type
Charakteristic
  • guided field
Exposure duration continuous for 48, 52, 56, 64, and 68 h
Modulation
Modulation type pulsed
Duty cycle 11.76 %
Repetition frequency 217 Hz
Additional info

German E-Network
Exposure setup
Exposure source
Setup Fitted into the removable waveguide wall was a rectangular sample holder that could hold 6 sample tubes of 17 mm diameter filled with 5 ml of medium which were circulated by temperature-controlled white oil and thus maintained at a constant temperature of 37 °C ± 0.1 °C.
Sham exposure A sham exposure was conducted.
Additional info A second identical sample holder for control tubes was placed into an RF-proof container.
Parameters
Measurand Value Type Method Mass Remarks
SAR 1,700 mW/kg mean calculated - -
Measurement and calculation details

The power fed into the waveguide was measured using a short monopole and a detector diode and was monitored by a computer throughout the experiment as well as the data supplied by two temperature sensors. SAR values averaged over the test tubes were determined by numerical simulations using FDTD. More detailed information can be found in the second article of the publication [Hansen et al., 1998].

Exposure 2

Main characteristics
Frequency 900 MHz
Type
Charakteristic
  • guided field
Exposure duration continuous for 48, 52, 56, 64, and 68 h
Modulation
Modulation type pulsed
Duty cycle 12 %
Repetition frequency 217 Hz
Additional info

German D-Network
Exposure setup
Exposure source
Sham exposure A sham exposure was conducted.
Parameters
Measurand Value Type Method Mass Remarks
SAR 208 mW/kg mean calculated - -

Exposure 3

Main characteristics
Frequency 380 MHz
Type
Charakteristic
  • guided field
Exposure duration continuous for 48, 52, 56, 64, and 68 h
Modulation
Modulation type pulsed
Pulse width 13.11 ms
Duty cycle 23.15 %
Repetition frequency 17.65 Hz
Additional info

German digital police radio
Exposure setup
Exposure source
Setup A round sample holder was placed on the bottom of the TEM cell.
Sham exposure A sham exposure was conducted.
Parameters
Measurand Value Type Method Mass Remarks
power 90 W peak value measured - -
SAR 82.9 mW/kg mean calculated - -

Reference articles

  • Hansen V et al. (1998): [The Effect of High-Frequency Electromagnetic Fields on Cell Cycle and Sister-Chromatid Exchanges: Analyses with Human Lymphocytes in Culture]

Exposed system:

Methods Endpoint/measurement parameters/methodology

Investigated system:
Time of investigation:
  • after exposure

Main outcome of study (acc. to author)

The velocity of cell cycle and the frequency of sister-chromatid exchange were not affected.

Study character:

Study funded by