Neurosciences. The elevated plus maze test is widely used tests for measuring anxiety-like behavior in rodents. The test is based on the natural aversion of mice and rats for open and elevated areas, as well as on their natural spontaneous exploratory behavior in novel environments. The apparatus consists of an open platform in the center of an elevated four-arm maze in which two opposite arms are open and two are enclosed. The rodents are given access to all of the arms and are allowed to move freely between them. The number of entries into the open arms and the time spent in the open arms are used as indices of open space-induced anxiety.